A/Prof Lim Seng Gee

  Senior Consultant, Division of Gastroenterology and Hepatology, National University Hospital (NUH)


Prof Lim currently serves as a Senior Consultant at the Division of Gastroenterology and Hepatology in the National University Hospital, Singapore. He is also a Professor in the Yong Loo Lin School of Medicine, National University of Singapore.

Prof Lim attained his basic medical degree with honours (MBBS Hons) from the University of Monash, Melbourne, Australia. He later pursued a doctorate degree (MD) in Monash and was awarded the FRACP (Australia), FRCP (London), FAMS (Gasteroenterology, Singapore).

His main clinical work focuses on the treatment of viral hepatitis (esp. B and C), liver disease and liver cancer. Prof Lim's research activities include leadership in Hepatology research, which focuses on improving treatment for chronic hepatitis B and C, pathophysiology of hepatitis B disease, HBV virology, immunological mechanisms of HBeAg seroconversion, and loss of immune tolerance to hepatitis B virus. He also has an interest in pathophysiology and treatment of liver cancer, primary hepatocyte culture, hepatocyte function, drug related liver disease and non-alcoholic fatty liver disease. Prof Lim has over 100 publications in peer review journals and sits on the editorial board of Liver International and GastroHep.com. He has received over S$5 million in research grants and is a reviewer for Singapore's grant funding agencies and the American Association for Liver Disease Annual Meeting.

Prof Lim also sits on the Advisory Board of Novartis Pharmaceuticals, Idenix Pharmaceuticals, Bristol Myers Squibb Pharmaceuticals and is on the Speaker's Bureau for GlaxoSmithKline and Schering Plough Pharmaceuticals. Prof Lim has been an invited speaker at AASLD, EASL and APASL in 2013, 2014 and is a regular speaker at numerous International and Regional meetings on liver disease and viral hepatitis


Education and Fellowships

Monash Medical School, Monash University,Clayton, Victoria, Australia and clinical campus: Alfred Hospital,Commercial Road, Prahran, Melbourne (1975-80).



Awards and Honours


  • Mathematics prize,MelbourneGrammar School, 1973

  • Runner-up for Final Year Clinical Prize,AlfredHospital, 1980. Second Class (Upper) honours 1980. Twentieth in class of 160.

  • Seah Cheng Siang Travelling Fellowship, 1995

  • Best poster award, Annual Scientific Meeting, Annual Scientific Meeting, Gastroenterological Society of Singapore, 2000.

  • Best oral presentation, Asia Pacific Association for Study of Liver Disease,Kyoto,Japan, 2007

  • Best poster award, Asia Pacific Association for Study of Liver Disease,Kyoto,Japan, 2007

  • Best oral presentation, Gastroenterology Society of Singapore Annual Scientific Meeting 2007

  • Presidential poster of distinction, American Association for Study of Liver Disease 2007

  • Best poster award, Asia Pacific Association for Study of Liver, Bangkok 2011 


Professional Memberships

  • Fellow of the Royal Australasian College of Physicians
  • Member, Gastroenterological Society of Singapore
  • Member, Gastroenterological Society of Australia
  • Member, Society of Infectious Diseases, Singapore
  • Member, International Society of Mucosal Immunology
  • Fellow,Academy of Medicine ofSingapore
  • Member, British Society of Gastroenterology
  • Member, American Gastroenterological Association
  • Member,Singapore Society of Transplantation
  • Member, American Association for Liver Disease
  • Council Member, Asia Pacific Association for Study of Liver 2006



Selected Publications (30 out of 217)

  1. S.G. Lim, I. Ikit, C.T. Wong. Intestinal parasites in schoolchildren ofSarawak. JournalPelajaran,Malaysia, 1974;2(1): 10-12.

  2. Mitchell,C.A.; Lim S.G. and Street, A.M. High dose IV gamma-globulin in haematological disease. Dev. Biol. Stand., 1987; 67: 267-72.

  3. Lim S.G.;Lee,C.A.; Kernoff, P.B.A. Therapy of HIV associated thrombocytopenia. Clinical and Laboratory Haematol., 1990; 12:237-45. (tier 4)

  4. Lim S.G.;Lee,C.A.; Kernoff, P.B.A., Zidovudine (AZT) in HIV positive haemophiliacs. Clinical and Laboratory Haematology, 1990; .12 :367 (tier 4)

  5. Lim S.G.;Lee,C.A.; Hales, M.; O’Doherty, M.; Winter, M.; Kernoff, P.B.A. Fluconazole for oropharyngal candidiasis in anti-HIV positive haemophiliacs. Aliment. Pharmacol. Therap., 1991; 5:199-205. (tier 2)

  6. Lim S.G.; Lee, C.A.; Charmain, H.; Tilsed, G.; Griffiths, P.D.; Kernoff, P.B.A. Hepatitis C antibody assay in a longitudinal study of haemophiliacs. Br. J. Haematol., 1991; 78: 398-402. (tier 2)

  7. Nwokolo, C.; Hudson, M; Lim S.G.; Prewett, E.; Sawyerr, A.; Pounder, R.E.; Tolerence to ranitidine 150 mg nocte : A 5 month placebo controlled study, double blind study. Gastroenterol., 1991; 101: 948-53. (tier 1)

  8. Quadri, M.I.; Lee, C.A.; Goodall, A.H.; Lim S.G.; Kernoff, P.B.A. Antibodies to platelet glycoprotein in haemophiliacs infected with HIV. Clin. Lab. Haematol., 1992, 14: 109-120. (tier 4)

  9. Lim S.G.; Sawyerr, A.;Hudson , M.; Pounder, R.E. The absorption of fluconazole and itraconazole absorption under conditions of low intragastric acidity. Aliment. Pharmacol. Ther. 1993; 7: 317-21. (toer 2)

  10. Lim S.G.; Menzies, I.S.; Lee, C.A.; Johnson, M.A.; Pounder, R.E. Intestinal permeability and function in patients infected with HIV: A comparison with Coeliac disease. Scan. J. Gastro., 1993; 28: 573-80 (tier 2)

  11. Lim S.G.; Lipman, M.; Squire, S.B.; Pillay, D., Emery, V.; Gillespie, S.; Sankey, L.; Dhillon, P.; Johnson, M.A.; Lee, C.A.; Pounder, R.E. The value of endoscopy and endoscopic surveillance biopsies in HIV-positive patients with gastrointestinal symptoms. Gut 1993; 34:1429-32. (tier 1)

  12. Lim S.G.; Condez, A.; Poulter, L.W. Mucosal macrophage subsets of the gut in HIV: decrease in antigen presenting cell phenotype. Clin. Exp. Immunol., 1993; 92; 442-7. (tier 2)

  13. Lim S.G.; Condez, A.; Lee, C.A.; Johnson, M.A.; Pounder, R.E.; Elia, E.; Poulter, L.W. Loss of mucosal CD4 lymphocytes is an early feature of HIV infection. Clin. Exp. Immunol. , 1993; 92: 448-54. (tier 2)

  14. Lim S.G.; Menzies, I.S.; Lee, C.A.; Johnson, M.A.; Pounder, R.E. Intestinal permeability and function in patients infected with human immunodeficiency virus: comparison with Coeliac disease. Gastroenterol. Digest 1994; May : 28-9

  15. Kaye,S.A.; Seifalian,A.M.; Lim,S.G.; Hamilton,G.; Black,C.M. Ischaemia of the small intestine in patients with systemic sclerosis:Raynaud’s phenomena or chronic vasculopathy?.Q.J.Med., 1994;87:495-500. (Tier 2)

  16. Lim S.G.; Menzies, I.S.; Murkajam, W.S.; Lee, C.A.; Johnson, M.A.; Pounder, R.E. Intestinal disaccharidase activity in patients infected with HIV. Scand. J. Gastroenterol. 1995; 30: 235-41. (tier 2)

  17. Kaye, S.A.; Lim S.G., Taylor, M.; Patel, S.; Gillespie, S.; Black, C.M. Small bacterial overgrowth in systemic sclerosis: detection using direct and indirect methods and treatment outcome. Brit. J. Rheumatol. 1995; 34: 265-9.

  18. Hua J, Yeoh KG, Ng HC, Zheng PY, Lim SG, Ho B. Improving the success of culturing Helicobacter pylori from gastric biopsies.  Microbios. 1998;96(384):95-101. (tier 4)

  19. Hua JS, Bow H, Zheng PY, Yeoh GK, Ng CH, Lim SG. Coexistence of Helicobacter pylori spiral and coccoid forms in experimental mice. World J Gastroenterol. 1998 Dec;4(6):485-488.

  20. Lim, S.G. “Informed Consent from an Asian Perspective” Acta Pharmacologica Sinica 1998; 19 suppl: 35. (tier 4)

  21. Fock, K.M.; Chelvam, P.; Lim S.G.; and the South-East Asia Multicentre Study Group. Triple therapy in the eradication of Helicobacter pylori in patients with duodenal ulcer disease: results of a multicentre study in South-East Asia. Aliment. Pharmacol. Ther., 2000; 14: 225-231. (tier 2)

  22. Wai Chun Tao, Lim Seng Gee, Tan Kai Chah. Outcome of lamivudine resistant hepatitis B virus infection in liver transplant recipients in Singapore (letter). Gut 2000;47:741. (tier 1)

  23. CT Wai, SK Lo, KH Lee, CK Tan, MM Aw, SH Quak, J Isaac, K Prabhakaran, SG Lim, KC Tan. 10 years experience of liver transplantation in Singapore. Transplantation Proceedings 2000 Dec;32(7):2139. (tier 4)

  24. CT Wai, SK Lo, KH Lee, CK Tan, J Isaac, K Prahakaran, SG Lim, KC Tan. Liver transplantation in hepatocellular carcinoma. Transplantation Proceedings 2000 Dec;32(7):2173. (tier 4)

  25. Saw Seang Mei, Lim Seng Gee. Clinical Drug Trials: Practical problems of Phase III. Ann Acad Med Singapore. 2000 Sep;29(5):598-605. (tier 4)

  26. Khu YL, Koh E, Lim SP, Tan YH, Brenner S, Lim SG, Hong WJ, Goh PY. Mutations that affect dimer formation and helicase activity of the hepatitis C virus helicase J Virol. 2001 Jan;75(1):205-14.  (tier 1)

  27. Lee, KH, Chun T Wai, SG Lim, Manjit Kaur, Hwee L Lee, Maureen Da Costa, SH Quak and Kai-Chah Tan. Risk of De Novo Hepatitis B from antibody to Hepatitis B Core Antigen-positive donors in Liver Transplantation in Singapore (Letter to Editor). Liver Transplant and Surgery, 2001; 7 (5).

  28. Nancy W.Y. Leung, Ching-Lung Lai, Ting-Tsung Chang, Richard Guan, Chuan-Mo Lee, Keng-Yeen Ng, Seng-Gee Lim, Pui-Chee Wu, Julie C. Dent, Sally Edmundson, Lynn D Condreay, Rong-Nan Chien on behalf of the Asia Hepatitis Lamivudine Study Group. Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: results after three years of therapy . Hepatology. 2001 Jun;33(6):1527-32. (tier

  29. Wai, DCT, KY Ho, KG Yeoh and SG Lim. Palliation of Malignant gastric cancer with self-expandable metal stents. Surgical Laparoscopy, Endoscopy and Percutaneous Techniques, 2001;11(3):161-4. (tier 3)

  30. Siew Pheng Lim, Yee Ling Khu, Wang Jin Hong, Alice Tay, Anthony Eugene Ting, Seng Gee Lim, Yin Hwee Tan. Identification and molecular characterisation of the complete genome of a Singapore isolate of hepatitis C virus: sequence comparison with other strains and phylogenetic analysis. Virus Genes 2001;23:89-95. (tier 3)