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Associate Professor Ng Siok Bian

 

Senior Consultant
National University Cancer Institute, Singapore (NCIS)
Department of Pathology, National University Hospital (NUH) 
 

Associate Professor
Department of Pathology, Yong Loo Lin School of Medicine
National University of Singapore (NUS)

Principal Associate

Cancer Science Institute of Singapore, NUS

Visiting Senior Consultant
Khoo Teck Puat Hospital, Singapore 


A/Prof Ng Siok Bian obtained her medical degrees from National University of Singapore and obtained Fellowship of the Royal College of Pathologists of Australasia in 2002. She subsequently completed her specialty training in haematolymphoid pathology as a visiting fellow at National Cancer Institute / National Institute of Health, Bethesda, USA, under the supervision of Dr ES Jaffe. A/Prof Ng joined the department of Pathology, NUS in 2007. She is currently the research director of the department of Pathology in National University Health System (NUHS).

 

A/Prof Ng’s diagnostic expertise is in haematolymphoid pathology and molecular pathology. Her research focus is on lymphomas, in particular EBV-associated T/NK-cell lymphomas, using a combinational analytical approach via gene and miRNA expression profiling on paraffin embedded tissue samples. Her group also has expertise in quantitative immunofluorescence using multispectral imaging platform.

 

Education and Fellowships 

MBBS (Singapore), FRCPA (Australia) 

 

Professional Memberships 

  • European Society of Haematopathology
  • Society of Haematopathology
  • Fellowship of Royal College of Pathologists of Australasia
  • United States and Canadian Academy of Pathologists 
  • National Healthcare Group Domain Specific Ethics Review Board 

 

Specialty Interests 

  • Haematolymphoid pathology
  • EBV-related lymphoproliferative disease

 

Selected Publications 

  1. Selvarajan V, Osato M, Nah GSS, Yan J, Chung TH, Voon DC, Ito Y, Ham MF, Salto-Tellez M, Shimizu N, Choo SN, Fan S, Chng WJ, Ng SB. RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC. Leukemia. 2017 Oct;31(10):2219-2227
  2. Ng SB, Ohshima K, Selvarajan V, Huang G, Choo SN, Miyoshi H, Wang S, Chua HC, Yeoh A, Quah TC, Koh LP, Tan PL, Chng WJ. Prognostic implication of morphology, cyclinE2 and proliferation in EBV-associated T/NK lymphoproliferative disease in non-immunocompromised hosts. Orphanet J Rare Dis. 2014 Dec 5;9:165.
  3. Ng SB, Ohshima K, Selvarajan V, Huang G, Choo SN, Miyoshi H, Shimizu N, Reghunathan R, Chua HC, Yeoh AE, Quah TC, Koh LP, Tan PL, Chng WJ. EBV-associated T/NK-cell lymphoproliferative disorder in children and young adults has similar molecular signature to extranodal nasal NK/T-cell lymphoma but shows distinctive stem cell-like phenotype. Leuk Lymphoma. 2015 Aug;56(8):2408-15.
  4. Yan J*, Ng SB*, Tay JL, Lin B, Koh TL, Tan J, Selvarajan V, Liu SC, Bi C, Wang S, Choo SN, Shimizu N, Huang G, Yu Q, Chng WJ. EZH2 overexpression in natural killer /T-cell lymphoma confers growth advantage independently of histone methyltransferase activity. Blood. 2013 May 30;121(22):4512-20.
  5. Ng SB, Yan J, Huang G, Selvarajan V, Tay JL, Lin B, Bi C, Tan J, Kwong YL, Shimizu N, Aozasa K, Chng WJ. Dysregulated microRNAs affect pathways and targets of biological relevance in nasal-type natural killer/T-cell lymphoma. Blood. 2011 Nov 3;118(18):4919-29.
  6. Ng SB, Selvarajan V, Huang G, Zhou J, Feldman AL, Law M, Kwong YL, Shimizu N, Kagami Y, Aozasa K, Salto-Tellez M, Chng WJ. Activated Oncogenic Pathways and Therapeutic Targets in Extranodal Nasal-Type NK/T Cell Lymphoma Revealed by Gene Expression Profiling. J Pathol. 2011 Mar;223(4):496-510.
  7. Ng SB, Khoury JD. Epstein-Barr Virus in Lymphoproliferative Processes: An update for the diagnostic pathologist. Adv Anat Pathol 2009 Jan; 16(1):40-55. [IF-3.476; Cited 10 times]
  8. Ng SB, Lee V, Das K, Salto-Tellez M. The relevance of molecular diagnostics in the practice of surgical pathology. Expert Opin. Med. Diagn. (2008) 2(11):1401-14.
  9. Ng SB, Lai KW, Murugaya S, Lee KM, Loong SL, Fook-Chong S, Tao M, Sng I. Nasal-type extranodal natural killer/T-cell lymphomas: a clinicopathologic and genotypic study of 42 cases in Singapore. Mod Pathol 2004;17(9):1097-1107.


Updated as of 27 October 2017