Dr Jonathan Lee

Associate Consultant, Department of Gastroenterology and Hepatology, National University Hospital (NUH)


Assistant Professor, National University of Singapore (NUS)


Dr Jonathan Lee is an Associate Consultant specialising in Gastroenterology and Hepatology at the National University Hospital, Singapore. He graduated from the University of New South Wales, Sydney with honours in 2010 and did his postgraduate residency training in NUH. He completed his fellowship in Gastroenterology and Hepatology, and was certified by the Specialist Accreditation Board of Singapore in 2017.


Dr Lee has a keen interest in endoscopic screening and treatment of gastrointestinal cancers. He is also skilled in diagnostic and therapeutic endoscopy, and is involved in colon cancer screening, endoscopic mucosal resection (EMR) of colon polyp and endoscopic submucosal dissection (ESD) of early gastrointestinal tumours.


Dr Lee's research interest is in the role of the microbiome associated with gastrointestinal diseases, and is actively involved in basic and translational research on this subject. He is also the principal investigator for ongoing studies in the field of microbiome and gastrointestinal diseases.  


Professional Memberships

  • 2014 - Member, Royal College of Physicians, Glasgow, UK
  • 2015 - Member, American Gastroenterology Association
  • 2017 - Faculty, NUH Research Sub-committee
  • 2017 - Faculty, Singapore Gastric Cancer Consortium
  • 2017 - Faculty, Asia-Pacific Digestive Week
  • 2017 - Alumni, CHKU-University of Melbourne Academy for Young Leaders
  • 2018 - Reviewer/Member, National Health Group Domain Specific Review Board E


Awards and Honours

  • 2016 - Clinical Scientist Unit 1st Prize
  • 2016 - 2017 - National Medical Research Council (NMRC) Research Training Fellowship
  • 2017 - GiHep 2017 meeting (Singapore) – Poster Presentation 2nd prize



  • Huang KK, Ramnarayanan K, Zhu F, Srivastava S, Xu C, Tan ALK, Lee M, Tay S, Das K, Xing M, Fatehullah A, Alkaff SMF, Lim TKH, Lee J, Ho KY, Rozen SG, Teh BT, Barker N, Chia CK, Khor C, Ooi CJ, Fock KM, So J, Lim WC, Ling KL, Ang TL, Wong A, Rao J, Rajnakova A, Lim LG, Yap WM, The M, Yeoh KG, Tan P. (2018) Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer. Cancer Cell. 2018 Jan 8;33(1):137-150.e5. doi: 10.1016/j.ccell.2017.11.018. Epub 2017 Dec 28.
  • Lee JW, Lim LG, Yeoh KG (2017). Advanced endoscopic imaging in gastric neoplasia and preneoplasia. BMJ Open Gastroenterol. Jan 16;4(1):e000105. doi: 10.1136/bmjgast-2016-000105. PubMed PMID: 28176895; PubMed Central PMCID: PMC5253458.
  • Koh JC, Loo WM, Goh KL, Sugano K, Chan WK, Chiu WY, Choi MG, Gonlachanvit S, Lee WJ, Lee YY, Lesmana LA, Li YM, Liu CJ, Matsuura B, Nakajima A, Ng EK, Sollano JD, Wong SK, Wong VW, Yang Y, Ho KY, Dan YY. (2016) Asian consensus on the relationship between obesity and gastrointestinal and liver diseases. J Gastroenterol Hepatol. Aug;31(8):1405-13. doi: 10.1111/jgh.13385. Review. PubMed PMID: 27010240.
  • Huynh H, Lee JW, Chow PK, Ngo VC, Lew GB, Lam IW, Ong HS, Chung A, Soo KC, (2009). Sorafenib induces growth suppression in mouse models of gastrointestinal stromal tumor. Molecular Cancer Therapeutics. 8(1): 152-9. PMID: 1913924.
  • Yang S, Ngo VC, Lew GB, Chong LW, Lee SS, Ong WJ, Lam WL, Thng CH, Koong HN, Ong HS, Chung A, Chow P, Lee JW, Soo KC, Huynh H, (2009). AZD 6244 enhances the therapeutic efficacy of Sorafenib in mouse models of gastric cancer. Molecular Cancer Therapeutics. 8(9): 2537-45. PMID: 19723882.


Research Support

  • Reduction in steatohepatitis through bacterial bile acid modification in the gut – [NUHS Clinician Scientist Programme award]
    • Principal Investigator
    • 15th Feb 2018 – 14th Feb 2020
  • Gut Dysbiosis associated with Non-Alcoholic Fatty Liver Disease – [Ministry of Health Research Fellowship Training Award]Gut Dysbiosis associated with Colorectal Cancer – [NUH Cancer Institute Seed Grant]
    • Principal Investigator
    • 2th May 2017 – 1st May 2019
    • Co-investigator
    • 2th May 2016 – 1st May 2018

Updated as of 9 May 2018