Dr Lee Guan Huei

Senior Consultant, Division of Gastroenterology & Hepatology, National University Health System


Assistant Professor, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore


Dr Lee Guan Huei obtained his medical degree from the National University of Singapore and the Royal College of Physicians of United Kingdom. After his advanced specialist training in Gastroenterology and Hepatology in the National University Hospital, he went on to complete a fellowship in King's College Hospital where he focused on the management of acute liver failure and liver transplantation in the liver intensive care unit. He has also been involved in clinical and translational research in hepatitis B virus, particularly in the areas of pathogenesis and drug resistance. He is currently working on the influence of epigenetic regulatory mechanisms on the hepatitis B episome with leading investigators in Singapore and Oxford. He has been the research director for the Division of Gastroenterology and Hepatology in NUHS since 2013.


Education and Fellowships



Specialty Interests

  • Viral hepatitis and liver cancer
  • Liver failure
  • Liver transplantation

Awards and Honours

  • National Medical Research Council, Medical Research Fellowship 2006-2009
  • Best Free Paper: GIHep Meeting 2008, Gastroenterological Society of Singapore
  • Singapore Clinician-Investigator Bronze Award - Singapore Health and Biomedical Congress 2010
  • Best Poster Award - GIHep Meeting 2013 by Gastroenterological Society of Singapore


Professional Memberships

  • Royal College of Physicians and Surgeons of Glasgow
  • Asia Pacific Association for the Study of Liver Disease
  • APASL ACLF Research Consortium
  • HepatoPancreatoBiliary Association (Singapore)
  • Gastroenteroloy Society of Singapore


Personal Hobbies and Interests

  • Long-standing passion in tennis and reading history

Selected Publications

  • Lee GH, Wasser S, Lim SG. Hepatitis B pregenomic RNA splicing--the products, the regulatory mechanisms and its biological significance. Virus Res. 2008 Sep;136(1-2):1-7. Epub 2008 Jun 11. 
  • Tan HH, Lee GH, Thia KTJ, Tan IK, Ng HS, WC Chow, Lui HF. Minimal Hepatic Encephalopathy Runs a Fluctuating Course: Results from a 3-Year Prospective Cohort Follow-Up Study. – Singapore Medical Journal 2009; 50 (3) : 255.
  • Lim LG, Aung MO, Seet BL, Tan C, Dan YY, Lee YM, Sutedja DS, Fernandes M, Lee GH, Koay E, Lim SG. Alanine aminotransferase is an inadequate surrogate marker for detecting lamivudine resistance. World J Gastroenterol. 2010;16(37):4691-6.
  • Lim SG, Aung MO, Mak B, Sutedja D, Lee YM, Lee GH, Fernandes M, Low HC, Lai V, Dan YY. Clinical outcomes of Lamivudine-adefovir therapy in chronic hepatitis B cirrhosis. J Clin Gastroenterol. 2011 Oct;45(9):818-23.
  • Guan Huei Lee, Myat Oo Aung, Yock Young Dan, Yin Mei Lee, Belinda Mak, Seng Gee Lim. Do Different Lamivudine-ResistantHepatitis B Genotypes Carry the Same Risk of Entecavir Resistance?J Med Virol. 2013 Jan;85(1):26-33.
  • Tan PS, Aung MO, Dan YY, Lee YM, Lim K, Low HC, Lee GH, Thwin MA, Soon C, Lim SG. Liver disease progression and virological response: entecavir rescue still possible in the setting of rtM204I lamivudine-resistant mutation. Gut 2013 May;62(5):801-2.
  • Guan-Huei Lee, Masafumi Inoue, Jimmy Kim-Pern Toh, Roxanne Hui-Heng Chong, Myat-Oo Aung, Seng-Gee Lim. Two-Step Evolution of the Hepatitis B Drug-Resistant Mutations in a Patient who Developed Primary Entecavir Resistance.Liver International 2013 Jan 24.
  • Seng Gee Lim, Guan Huei Lee, Kieron Lim, Poh Seng Tan. Resistance is No Longer a Problem with Entecavir and Tenofovir. Current Hepatitis Reports 2013 Jun 1(12):96-104.
  • JL Hartono, MO Aung, YY Dan, M Gowans, K Lim, YM Lee, GH Lee, HC Low, B Mak, MA Thwin, Lily- L Chiu, MJ Khoo, E Koay, SG Lim. Resolution of Adefovir-related nephrotoxicity by Adefovir dose reduction in patients with chronic hepatitis B. Alimentary Pharmacology & Therapeutics 2013 Apr;37(7):710-9. 

Updated as of 1 July 2017