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Associate Professor Mikael Hartman


Senior Consultant, Breast and Trauma Surgery, National University Hospital (NUH) 

Associate Professor, Saw Swee Hock School of Public Health, National University of Singapore (NUS)

Associate Professor, Yong Loo Lin School of Medicine, Department of Surgery, NUS 

Adjunct Staff, Department of Medical Epidemiology, Karolinska Institute, Sweden

 

A/Prof Mikael Hartman has been practicing in Singapore since 2009 and is originally from Stockholm, Sweden where he received his training at Karolinska Institute. That is also where he received his board certification in General Surgery in 2005. Having completed his doctoral studies in the field of epidemiology in 2007, he specializes in the field of breast cancer etiology and prognostification as well as inheritance of cancer prognosis. He has been a co-recipient of the Breast Cancer Concept Award, US Army, in 2002 and 2006.

 

He heads a research group of more than ten members including three PhD students and is leading the development of the Singapore Breast Cancer Cohort and the Singapore-Malaysia Breast Cancer Working Group and the Breast Cancer Prevention Programme in the Saw Swee Hock School of Public Health (SSHSPH). The research has been published in Lancet Oncology, Journal of Clinical Oncology, Breast Cancer Research, British Journal of Surgery, European Journal of Cancer etc. He serves as the Deputy Director of the Initiative for Research and Innovation in Surgery – NUHS, the Research Director of the University Surgical Cluster Research Committee – NUHS, the Head of Surgical Clinical Epidemiology Unit – NUHS, Deputy Head of Breast Services in Department of Surgery – NUH and a member of SSHSPH Senior Management Committee and Faculty Promotion and Tenure Committee.

 

He is a father of 3 children with a keen interest in skiing, hiking and mountain biking. In 2014 he made an effort to create awareness for breast cancer and research by riding a motorcycle from Singapore to Sweden.

 

Support project “The Long Ride 2014: Singapore to Sweden for Breast Cancer Research”. Visit http://medicine.nus.edu.sg/medsur/thelongride/

 

Education and Fellowships

MD (Stockholm), PhD (Karolinska Institute) 

 

Specialty Interests

  • Breast cancer etiology
  • Breast cancer prognostication
  • Inheritance of prognosis
  • Pharmacogenomic
  • Clinical epidemiology
  • Trauma

 

Professional Highlights

  • 50+ peer reviewed articles in high ranking international journals
  • Principle Investigator of 20+ projects

 

Awards and Honours

  • Breast Cancer Concept Award 2002, US Army, Congressionally Directed Medical Research Programs
  • Breast Cancer Concept Award 2006, US Army, Congressionally Directed Medical Research Programs
  • Best Poster Presentation International Surgical Society (ISS) Meeting 2009, Adelaide, Australia 
  • Recipient of NMRC Clinician Scientist Award

 

Selected Publications (Since 2005)

 

  1. Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. Dunning Am,…, Hartman M,…, Edwards Sl. Nat Genet. 2016 Feb.
  2. Familial Risk and Heritability of Cancer Among Twins in Nordic Countries. Mucci LA,…, Hartman,…,  Kaprio J. JAMA. 2016 Feb.
  3. Genomic landscapes of breast fibroepithelial tumors. Tan J,…, Hartman M,…, Teh BT. Nat Genet. 2015 Nov.
  4. Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression. Darabi H,…, Hartman M,…, Chenevix-Trench G. Am J Hum Genet. 2015 Jul.
  5. Female breast cancer incidence among Asian and Western populations: more similar than expected. Sung H,…,Hartman M,…, Yang XR. J Natl Cancer Inst. 2015 Apr.
  6. Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. Michailidou K,…, Hartman M,…, Easton DF. Nat Genet. 2015 Apr. 
  7. Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1. Glubb DM,…, Hartman M,…, French JD. Am J Hum Genet. 2015 Jan. 
  8. Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation. Ghoussaini M,…, Hartman,…, Dunning AM. Nat Commun. 2014 Sep.
  9. Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1. Cai Q,…, Hartman M,…, Zheng W. Nat Genet. 2014 Aug. 
  10. Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma. Lim WK,…, Hartman M,…, Teh BT. Nat Genet. 2014 Aug.
  11. Mammographic density phenotypes and risk of breast cancer: a meta-analysis. Pettersson A,…, Hartman M,…, Tamimi RM. J Natl Cancer Inst. 2014 Apr.
  12. Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Garcia-Closas M, …, Hartman M,…, Kraft P. Nat Genet. 2013 Apr.
  13. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Bojesen SE,…, Hartman M,…, Dunning AM. Nat Genet. 2013 Apr.
  14. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Michailidou K,…, Hartman M,…, Easton DF. Nat Genet. 2013 Apr.
  15. Incidence and outcome of male breast cancer: An international population based study. Miao H,…, Hartman M, Yip CH. J Clin Oncol. 2011 Jun.
  16. Molecular epidemiology and its current clinical use in cancer management. Hartman M, Loy EY, Ku CS, Chia KS. Lancet Oncol. 2010 Apr.
  17. Breast cancer onset in twins and women with bilateral disease. Hartman M, Hall P, Edgren G,…, Czene K. J Clin Oncol. 2008 Sep.
  18. Familial concordance in cancer survival: a Swedish population-based study. Lindström LS, Hall P, Hartman M,..., Czene K. Lancet Oncol. 2007 Nov.
  19. Incidence and prognosis of synchronous and metachronous bilateral breast cancer Hartman M, Czene K,…, Hall P. J Clin Oncol. 2007 Sep.
  20. Genetic implications of bilateral breast cancer: A population-based cohort study Hartman M, Czene K,…, Hall P. Lancet Oncol. 2005 Jun.

 


Updated as of 19 May 2016