Professor Aileen Wee

Senior Consultant, Department of Pathology

Professor Aileen Wee graduated from the University of Singapore in 1975 with MBBS. She trained in Histopathology at the Department of Pathology, NUS, and obtained her specialist degree in Histopathology from the Royal Colleges of Pathologists in Australasia and the United Kingdom in 1981 and 1982, respectively. She has been a member of the American Association for the Study of Liver Diseases since 1984 and a member of the Laennec Liver Pathology Society since 2008. Her research interests include fine needle aspiration biopsy of liver, and gastrointestinal and hepatobiliary pathology, including liver transplantation pathology. She is currently working on the liver biopsy validation of liver fibrosis/cirrhosis with magnetic resonance elastography and Fibro-C-index (A computer-assisted image-based quantitative system). Professor Wee is a reviewer and advisor on several regional/international journals, has published over 100 articles in peer-reviewed journals and is co-author of several books. Professor Wee organizes regular Diagnostic Cytopathology Workshops and has travelled extensively in the region and internationally to deliver invited lectures at scientific meetings and to conduct cytopathology and hepatobiliary workshops. She is Director of Undergraduate Pathology Teaching and is currently the Phase II Co-ordinator for the medical undergraduate programme at YLLSoM. She was past Chair of the Specialist Training Committee (Pathology) in Singapore and was a member of the Specialist Accreditation Board, Singapore. She received the National University of Singapore Faculty of Medicine Teaching Excellence Award (1997/1998). She was conferred the 2009 Singapore Society of Pathology-Becton Dickinson Award for Pathology.

Education and Fellowships

MBBS NUS, FRCPath, FRCPA

Specialty Interests

• Hepatobilary pathology
• Liver transplantation pathology
• Fine-needle aspiration cytology of liver
• Biopsy validation of liver fibrosis/cirrhosis with magnetic resonance elastography and Fibro-C-index (A computer-assisted image-based quantitative system)

Specialises in Diseases and Conditions

• Hepatobilary diseases
• Hepatobilary cancers
• Liver transplantation pathology

Professional Highlights

• Phase II Co-ordinator, Undergraduate Medical Curriculum, Yong Loo Lin School of Medicine
• Director of Undergraduate Medical Education, Department of Pathology, YLLSoM
• Programme director, Diagnostic Cytopathology Workshops, NUHS
• Collaborator with Institute of Bioengineering and Nanotechnology (IBN), A*Star on: Morphology-based quantification of liver fibrosis using second harmonic generation and two-photon microscopy.

Awards and Honours

• Teaching Excellence Award, Medical Faculty, 1997-98, National University of Singapore
• Singapore Society of Pathology-Becton Dickinson Award for Pathology, 2009

Selected Publications

1. Wee A and P Sampatanukul. Fine needle aspiration cytology of the liver. Diagnostic Algorithms. A Southeast Asian perspective. Bangkok: Year Book Publisher Co., Ltd, 2004.
2. Wee A. Distinction between Well-differentiated Hepatocellular Carcinoma and Benign Hepatocellular Nodular Lesions, using Fine-needle Aspiration Biopsy. In Handbook of Immunohistochemistry and in situ hybridization of Human Carcinomas, Volume 3. Molecular Genetics, Liver Carcinoma, and Pancreatic Carcinoma. Ed. M.A. Hayat, 247-259. Elsevier Academic Press, London. 2005.
3. Bosman FT, Carniero F, Hruban RH, Thiese N (Eds). WHO Classification of Tumours of the Digestive System. IARC: Lyon 2010.
4. Goodman ZD, Luigi Terracciano, Wee A. Tumours and tumour like lesions. In MacSween’s Pathology of the Liver, 6th edition, Eds AD Burt, BC Portmann, LD Ferrell. Churchill Livingstone, Elsevier (in press).

Journals

1. Tai, Dean, Nancy Tan, Shuoyu Xu, Chiang Huen Kang, Ser Mien Chia, Chee Leong Cheng, A Wee, CL Wei, Raja Anju Mythreyi, G XIAO, S Chang, Jagath Rajapakse, PT So, HH Tang, CS Chen and H Yu. Fibro-C-Index: comprehensive, morphology-based quantification of liver fibrosis using second harmonic generation and two-photon microscopy. J Biomedical Optics, 14, no. 4 (2009): 044013.
2. Rajkumar, S D, B P Pereira, Y Zou, P Gopalakrishnakone, CL Cheng, A Wee and E J D Lee. Role of multi-drug resistance-associated protein-1 transporter in statin-induced myopathy. Life Sciences, 82, no. 15-16 (2008): 823-830.
3. Salto-tellez, M, M E Nga, H C Han, A Wong, C K Lee, D B A NUR, M Ho, A Wee, S S Ng and R Soong. Tissue Microarrays Characterize the Clinical Significance of a VEGF-A Protein Expression Signature in Gastrointestinal Stromal Tumors. British Journal of Cancer, 96, no. 5 (2007): 776-782.
4. Lim, S G, C T Wai, Y M Lee, Y Y Dan, D S Sutedja, A Wee, S Suresh, J W Ying, D Machin, C C Lim, K M Fock, E S C Koay, S Bowden, S Locarnini and S M Ishaque. A randomized, placebo-controlled trial of thymosin-alpha1 and lymphoblastoid interferon for HBeAg-positive chronic hepatitis B. Antiviral Therapy, 11, no. 2 (2006): 245-253.
5. Low, H C, M Da Costa, K Prabhakaran, M Kaur, A Wee, S G Lim and C T Wai. Impact of new legislation on presumed consent on organ donation on liver transplant in Singapore: A preliminary analysis. Transplantation, 82, no. 9 (2006): 1234-1237.
6. Wee A. Fine needle aspiration biopsy of the liver: Algorithmic approach and current issues in the diagnosis of hepatocellular carcinoma. Cytojournal, 2, no. 7 (2005).