Professor Aileen Wee

Senior Consultant, Department of Pathology, National University Hospital (NUH)                                           

Professor Aileen Wee graduated from the University of Singapore in 1975 with MBBS. She trained in Histopathology at the Department of Pathology, NUS, and obtained her specialist degree in Histopathology from the Royal Colleges of Pathologists in Australasia and the United Kingdom in 1981 and 1982, respectively. She has been a member of the American Association for the Study of Liver Diseases since 1984 and a member of the Laennec Liver Pathology Society since 2008.


Her research interests include fine needle aspiration biopsy of liver, and gastrointestinal and hepatobiliary pathology, including liver transplantation pathology. Professor Wee is a reviewer and advisor on several regional/international journals, has published over 145 articles in peer-reviewed journals and is co-author of several books and book chapters.


Professor Wee organizes regular Diagnostic Cytopathology Workshops and has travelled extensively in the region and internationally to deliver invited lectures at scientific meetings and to conduct cytopathology, hepatobiliary pathology and liver transplantation pathology workshops. She was Director of Undergraduate Pathology Teaching and Phase II Co-ordinator for the medical undergraduate programme at YLLSoM. She was past Chair of the Specialist Training Committee (Pathology) in Singapore and was a member of the Specialist Accreditation Board, Singapore.



Education and Fellowships




Specialty Interests

  • Hepatobiliary pathology
  • Liver transplantation pathology
  • Fine-needle aspiration cytology of liver



Professional Highlights

  • Phase II Co-ordinator, Undergraduate Medical Curriculum, Yong Loo Lin School of Medicine (till 2012)
  • Director of Undergraduate Medical Education, Department of Pathology, YLLSoM (till 2012)
  • Course Director, Diagnostic Cytopathology Workshops, NUHS



Awards and Honours

  • Teaching Excellence Award, Medical Faculty, 1997-98, National University of Singapore
  • Singapore Society of Pathology-Becton Dickinson Award for Pathology, 2009
  • Certificate of Commendation for Being a Role Model to the Class of 2014, Yong Loo Lin School of Medicine, National University of Singapore
  • Special Recognition Award for being Role Model to the Medicine Graduating Class of 2015, Yong Loo Lin School of Medicine, National University of Singapore


Selected Publications


Books/Book Chapters


  1. Wee A and P Sampatanukul. Fine needle aspiration cytology of the liver. Diagnostic Algorithms. A Southeast Asian perspective. Bangkok: Year Book Publisher Co. Ltd, 2004.
  2. Wee A. Distinction between Well-differentiated Hepatocellular Carcinoma and Benign Hepatocellular Nodular Lesions, using Fine-needle Aspiration Biopsy. In: Handbook of Immunohistochemistry and in situ hybridization of Human Carcinomas, Volume 3. Molecular Genetics, Liver Carcinoma, and Pancreatic Carcinoma. Ed. M.A. Hayat, 247-259. Elsevier Academic Press, London, 2005.
  3. Wee A. In: Bosman FT, Carniero F, Hruban RH, Thiese N (Eds). WHO Classification of Tumours of the Digestive System. IARC: Lyon, 2010.
  4. Wee A, Sampatanukul P, Jhala N. Cytohistology of Focal Liver Lesions. In: Eds. K Geisinger and MB Pitman. Cytohistology of Small Tissue Samples series. Cambridge University Press, 2014.
  5. Wee A and Pitman MB. Diagnostic Liver Cytology. In: Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas. Eds. R Odze & J Goldblum. Elsevier, 2014.
  6. Linda D. Ferrell, Sanjay Kakar, Luigi M. Terracciano, Aileen Wee. Tumours and tumour-like Lesions of the Liver. In: MacSween’s Pathology of the Liver, 7th edition. Eds. Alastair D. Burt, Linda D. Ferrell, Stefan G. Hubscher, Elsevier, 2017.



  • Sun Y, Zhou JL, Wang L,…..Wee A, Theise ND, You H, Jia JD. New classification of liver biopsy assessment for fibrosis in chronic hepatitis B patients before and after treatment. Hepatology 2017;65:1438-50.
  • Hennedige TP, Wang G, Leung FP, ….Wee A, Venkatesh SK. Magnetic resonance elastography and diffusion weighted imaging in the evaluation of hepatic fibrosis in chronic hepatitis B. Gut and Liver, 2017;11:401-8.
  • Gupta K, Li Q, Fan JJ, Fong E,……Wee A, Dan YY, ….Yu H. Actomyosin contractility drives bile regurgitation as an early response during obstructive cholestasis. J Hepatol 2017; 66:1231-40.
  • Hennedige TP, Hallinan JT, Leung FP, Teo LL, Iyer S, Wang G, Chang S, Madhavan KK, Wee A, Venkatesh SK.  Comparison of magnetic resonance elastography and diffusion-weighted imaging for differentiating benign and malignant liver lesions.  Eur Radiol 2016; 26: 398-406. EPUD 2015 Jun2.
  • Lee GH, Tan BH, Chi-Yuan Teo E, Lim SG, Dan YY, Wee A, Kim Aw, PP, Zhu Y, Hibberd ML, Tan CK, Purdy MA, Teo CG.  Chronic Infection with Camelid Hepatitis E Virus in a Liver Transplant Recipient Who Regularly Consumes Camel Meat and Milk.  Gastroenterology. 2016; 150(2): 355-357.
  • Wee A, Soon G. Review article.  Liver transplantation: From a histopathologist’s perspective. Pak Armed Forces Med J 2016; 66(1): 127-135.
  • Wee A.  Review article.  The Many Faces (and Origins) of Adenocarcinoma in the Liver: Pattern Approach to Diagnosis on Small Tissue Samples.  Asian Arch Pathol 2015:11:1-25.
  • Wee A, Sampatanukul P.  Cytohistology of Hepatocellular Carcinoma. Diag Histopathol 2015; 12: 470-480.
  • Sanjay de Mel, B Wong, L Gole, CB Ng, E Koay, CWS Ng, JE Seet, A Wee, WJ Chng, LK Tan.  A rare variant of aggressive T-cell large granular lymphocyte leukemia associated with hepatic fibrosis and trisomy 8: A case report and literature review. J Hematol 2015; 4(3): 214-218





Updated as of 27 October 2017