Research Publication Highlights

Selected Publications: Jan - Jun 2017


  1. Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry. Breast Cancer Res. 2016 Dec 8. 18(1):124. Wen W, … Hartman M, …Zheng We et al.
  2. A comparison of attitudes toward length and quality of life between community-dwelling older adults and patients with advanced cancer. Psychooncology. 2016 Dec 10. doi: 10.1002/pon.4344. Malhotra C, Xiang L, Ozdemir S, Kanesvaran R, Chan N, Finkelstein EA.
  3. Activation of mutant TERT promoter by RAS-ERK signaling is a key step in malignant progression of BRAF-mutant human melanomas. Proc Natl Acad Sci U S A. 2016 Dec 13. 113(50):14402-14407. Li Y, Cheng HS, Chng WJ, Tergaonkar V.
  4. Thinking out of the gut: A case of obscure lower GI bleeding. Gut. 2016 Dec 13. pii: gutjnl-2016-313252. doi: 10.1136/gutjnl-2016-313252. Koh FH, Chan HL, Petersson F, Chong CS.
  5. Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems. Breast Cancer Res. 2016 Dec 19. 18(1):130. Burton A, … Hartman M, … McCormack VA et al.
  6. Aberrant localization of apoptosis protease activating factor-1 in lipid raft sub-domains of diffuse large B cell lymphomas. Oncotarget. 2016 Dec 20. 7(51):83964-83975. doi: 10.18632/oncotarget.13336. Hirpara JL, Loh T, Ng SB, Chng WJ, Pervaiz S.
  7. EGFR kinase inhibitors and gastric acid suppressants in EGFR-mutant NSCLC: A retrospective database analysis of potential drug interaction. Oncotarget. 2016 Dec 20. 7(51):85542-85550. doi: 10.18632/oncotarget.13458. Kumarakulasinghe NB, Syn N, Soon YY, Asmat A, Zheng H, Loy EY, Pang B, Soo RA.
  8. Knockdown of POLA2 increases gemcitabine resistance in lung cancer cells. BMC Genomics. 2016 Dec 22. 17(Suppl 13):1029. doi: 10.1186/s12864-016-3322-x. Koh V, Kwan HY, Tan WL, Mah TL, Yong WP.
  9. High-risk HPV genotypes and P16INK4a expression in a cohort of head and neck squamous cell carcinoma patients in Singapore. Oncotarget. 2016 Dec 27. 7(52):86730-86739. doi: 10.18632/oncotarget.13502. Tan LS, Fredrik P, Ker L, Yu FG, Wang Y, Goh BC, Loh KS, Lim CM.
  10. A safe method for middle colic dissection and ligation at its origin in a laparoscopic extended right hemicolectomy. Ann Surg Oncol. 2016 Dec. 23(Suppl 5):665. Koh FH, Tan KK.
  11. Are we ready for the use of intraoperative salvaged blood in metastatic spine tumour surgery? Eur Spine J. 2016 Dec. 25(12):3997-4007. Kumar N, Ahmed Q, Lee VK, Zaw AS, Goy R, Wong HK.
  12. Ascochlorin enhances the sensitivity of doxorubicin leading to the reversal of epithelial-to-mesenchymal transition in hepatocellular carcinoma. Mol Cancer Ther. 2016 Dec. 15(12):2966-2976. Dai X, Ahn KS, Wang LZ, Kim C, Deivasigamni A, Arfuso F, Um JY, Kumar AP, Chang YC, Kumar D, Kundu GC, Magae J, Goh BC, Hui KM, Sethi G.
  13. ATM expression predicts veliparib and irinotecan sensitivity in gastric cancer by mediating P53-independent regulation of cell cycle and apoptosis. Mol Cancer Ther. 2016 Dec. 15(12):3087-3096. Subhash VV, Tan SH, Yeo MS, Yan FL, Peethala PC, Liem N, Krishnan V, Yong WP.
  14. Comprehensive mutational analysis of primary and relapse acute promyelocytic leukemia. Leukemia. 2016 Dec. 30(12):2430. doi: 10.1038/leu.2016.237. Madan V, Shyamsunder P, Han L, Mayakonda A, Nagata Y, Sundaresan J, Kanojia D, Yoshida K, Ganesan S, Hattori N, Fulton N, ..., Koeffler HP.
  15. Fluorescent angiography used to evaluate the perfusion status of anastomosis in laparoscopic anterior resection. Ann Surg Oncol. 2016 Dec. 23(Suppl 5):692. Koh FH, Tan KK.
  16. Inhibition of MMP activity can restore NKG2D ligand expression in gastric cancer, leading to improved NK cell susceptibility. J Gastroenterol. 2016 Dec. 51(12):1101-1111. Shiraishi K, … Kua LF, … Shabbir A, Yong WP, So J, … Kono K et al.
  17. Intraoperative cell salvage in metastatic spine tumour surgery reduces potential for reinfusion of viable cancer cells. Eur Spine J. 2016 Dec. 25(12):4008-4015. Epub 2016 Mar 7. Kumar N, Zaw AS, Khoo BL, Nandi S, Lai Z, Singh G, Lim CT, Thiery JP.
  18. Isochromosome 17q; A novel finding in myeloid sarcoma. J Clin Exp Hematop. 2016 Dec. 56(2):130-134. de Mel S, Lee J, Chua C, Chua SP, Gole L, Poon L, Li J, Ng SB, Liu TC, Chng WJ, Chee YL.
  19. Prevalence and predictors of bias in the reporting of primary efficacy and toxicity endpoints in randomized clinical trials of radiation oncology. J Med Imaging Radiat Oncol. 2016 Dec. 60: 764–771. doi:10.1111/1754-9485.12494. Teng HT, Chen D, Soon YY, Tey J.
  20. Water as neutral oral contrast agent in abdominopelvic CT: comparing effectiveness with Gastrografin in the same patient. Med Journal Malaysia. Dec 2016. 71 (6). Lee C, Gu H, Vellayappan B, Tan C.
  21. Unilateral pelvic side-wall lymph node resection for rectal cancer: A review of the anatomy. Ann Surg Oncol. 2016 Dec. 23(Suppl 5):693. Lim TZ, Lee PJ, Solomon MJ, Tan KK.
  22. Concordance of two approaches in monitoring of minimal residual disease in B-precursor acute lymphoblastic leukemia: Fusion transcripts and leukemia-associated immunophenotypes. J Formos Med Assoc. 2017 Jan 4. pii: S0929-6646(16)30480-6. doi: 10.1016/j.jfma.2016.12.002. Huang YJ, Coustan-Smith E, Kao HW, Liu HC, Chen SH, Hsiao CC, Yang CP, Jaing TH, Yeh TC, Kuo MC, Lai CL, Chang CH, Campana D, Liang DC, Shih LY.
  23. Limb hypothermia for preventing paclitaxel-induced peripheral neuropathy in breast cancer patients: A pilot study. Front Oncol. 2017 Jan 10. 6:274. doi: 10.3389/fonc.2016.00274. Sundar R, Bandla A, Tan SS, Liao LD, Kumarakulasinghe NB, Jeyasekharan AD, Ow SG, Ho J, Tan DS, Lim JS, Vijayan J, Therimadasamy AK, Hairom Z, Ang E, Ang S, Thakor NV, Lee SC, Wilder-Smith EP.
  24. A murine orthotopic bladder tumor model and tumor detection system. J Vis Exp. 2017 Jan 12. (119). doi: 10.3791/55078. Tham SM, Esuvaranathan K, Mahendran R.
  25. Mutational landscape of pediatric acute lymphoblastic leukemia. Cancer Res. 2017 Jan 15. 77(2):390-400. doi: 10.1158/0008-5472.CAN-16-1303. Ding LW, Sun QY, Tan KT, Chien W, Thippeswamy AM, Eng Juh Yeoh A, Kawamata N, Nagata Y, Xiao JF, Loh XY, Lin DC, Garg M, Jiang YY, Xu L, Lim SL, Liu LZ, Madan V, Sanada M, Fernendez LT, Preethi H, Lill M, Kantarjian HM, ..., Koeffler HP, et al.
  26. Advanced endoscopic imaging in gastric neoplasia and preneoplasia. BMJ Open Gastroenterol. 2017 Jan 16. 4(1):e000105. doi: 10.1136/bmjgast-2016-000105. eCollection 2017. Lee JW, Lim LG, Yeoh KG.
  27. Are hemoglobin levels really lower in faecal immunochemical test positive patients with colorectal cancer? Surgeon. 2017 Jan 17. pii: S1479-666X(16)30085-3. doi: 10.1016/j.surge.2016.12.001. Ng JY, Tan IJ, Tan KK.
  28. Clinical implications of DNMT3A mutations in a Southeast Asian cohort of acute myeloid leukaemia patients. J Clin Pathol. 2017 Jan 18. pii: jclinpath-2016-204195. doi: 10.1136/jclinpath-2016-204195. Tan M, Ng IK, Chen Z, Ban K, Ng C, Chiu L, Seah E, Lin M, Tai BC, Yan B, Ng CH, Chng WJ.
  29. Is gastroscopy for fecal immunochemical test positive patients worthwhile? Int J Colorectal Dis. 2017 Jan. 32(1):95-98. doi: 10.1007/s00384-016-2666-7. Ng JY, Chan DK, Tan KK.
  30. Thiol-ol chemistry for grafting of natural polymers to form highly stable and efficacious antibacterial coatings. ACS Appl Mater Interfaces. 2017 Jan 18. 9(2):1847-1857. doi: 10.1021/acsami.6b10240. Li M, Mitra D, Kang ET, Lau T, Chiong E, Neoh KG.
  31. Association between environmental tobacco smoke exposure and the occurrence of EGFR mutations and ALK rearrangements in never-smokers with non-small-cell lung cancer: Analyses from a prospective multinational ETS registry. Clin Lung Cancer. 2017 Jan 19. pii: S1525-7304(17)30020-7. doi: 10.1016/j.cllc.2017.01.005. Soo RA, Kubo A, Ando M, Kawaguchi T, Ahn MJ, Ou SI.
  32. Evaluation of a brief pilot psychoeducational support group intervention for family caregivers of cancer patients: a quasi-experimental mixed-methods study. Health Qual Life Outcomes. 2017 Jan 23. 15(1):17. doi: 10.1186/s12955-017-0595-y. Mahendran R, Lim HA, Tan JY, Ng HY, Chua J, Lim SE, Kua EH, Griva K.
  33. Wanted DEAD/H or Alive: Helicases Winding Up in Cancers. J Natl Cancer Inst. 2017 Jan 25. 109(6). pii: djw278. doi: 10.1093/jnci/djw278. Cai W, Xiong Chen Z, Rane G, Satendra Singh S, Choo Z, Wang C, Yuan Y, Zea Tan T, Arfuso F, Yap CT, Pongor LS, Yang H, Lee MB, Cher Goh B, Sethi G, Benoukraf T, Tergaonkar V, Prem Kumar A.
  34. Novel exon-exon breakpoint in CIC-DUX4 fusion sarcoma identified by anchored multiplex PCR (Archer FusionPlex Sarcoma Panel). J Clin Pathol. 2017 Jan 30. pii: jclinpath-2016-204247. doi: 10.1136/jclinpath-2016-204247. Loke BN, Lee VK, Sudhanshi J, Wong MK, Kuick CH, Puhaindran M, Chang KT.
  35. Clarifying the debate on population-based screening for breast cancer with mammography: A systematic review of randomized controlled trials on mammography with Bayesian meta-analysis and causal model. Medicine (Baltimore). 2017 Jan. 96(3):e5684. doi: 10.1097/MD.0000000000005684. Review. Chen TH, Yen AM, Fann JC, Gordon P, Chen SL, Chiu SY, Hsu CY, Chang KJ, Lee WC, Yeoh KG, Saito H, Promthet S, Hamashima C, Maidin A, Robinson F, Zhao LZ.
  36. Emerging biomarkers for PD-1 pathway cancer therapy. Biomark Med. 2017 Jan. 11(1):53-67. Lim JS, Sundar R, Chenard-Poirier M, Lopez J, Yap TA.
  37. Feasibility study of toxicity outcomes using GEC-ESTRO contouring guidelines on CT based instead of MRI-based planning in locally advanced cervical cancer patients. Brachytherapy. 2017 Jan - Feb. 16(1):126-132. doi: 10.1016/j.brachy.2016.09.009. Koh V, Choo BA, Lee KM, Tan TH, Low JH, Ng SY, Ilancheran A, Shen L, Tang J.
  38. Glioblastoma multiforme outcomes of 107 patients treated in two Singapore institutions. Singapore Med J. 2017 Jan. 58(1):41-45. doi: 10.11622/smedj.2016044. Cheo ST, Lim GH, Lim KH.
  39. Identification of Stem Cells in the Epithelium of the Stomach Corpus and Antrum of Mice. Gastroenterology. 2017 Jan. 152(1):218-231.e14. doi: 10.1053/j.gastro.2016.09.018. Matsuo J, Kimura S, Yamamura A, Koh CP, Hossain MZ, Heng DL, Kohu K, Voon DC, Hiai H, Unno M, So JB, Zhu F, Srivastava S, Teh M, Yeoh KG, Osato M, Ito Y.
  40. Labia Majora Share. Arch Plast Surg. 2017 Jan. 44(1):80-84. doi: 10.5999/aps.2017.44.1.80. Lee H, Yap YL, Low JJ, Lim J.
  41. Longitudinal study of the protective effect of hope on reducing body image distress in cancer patients. J Psychosoc Oncol. 2017 Jan-Feb. 35(1):77-89. Liu J, Griva K, Lim HA, Tan JY, Mahendran R.
  42. Measuring outcomes of mindfulness interventions. Br J Psychiatry. 2017 Jan. 210(1):84-85. doi: 10.1192/bjp.210.1.84a. Mahendran R, Kua EH.
  43. Molecular mechanism and therapeutic implications of selinexor (KPT-330) in liposarcoma. Oncotarget. 2017 Jan 31. 8(5):7521-7532. doi: 10.18632/oncotarget.13485. Garg M, Kanojia D, Mayakonda A, Said JW, Doan NB, Chien W, Ganesan TS, Chuang LS, Venkatachalam N, Baloglu E, Shacham S, Kauffman M, Koeffler HP.
  44. Mutational profiling of a MonoMAC syndrome family with GATA2 deficiency. Leukemia. 2017 Jan. 31(1):244-245. doi: 10.1038/leu.2016.256. Ding LW, Ikezoe T, Tan KT, Mori M, Mayakonda A, Chien W, Lin DC, Jiang YY, Lill M, Yang H, Sun QY, Koeffler HP.
  45. Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD). Leukemia. 2017 Jan. 31(1):1-10. doi: 10.1038/leu.2016.160. Sun QY, Ding LW, Tan KT, Chien W, Mayakonda A, Lin DC, Loh XY, Xiao JF, Meggendorfer M, Alpermann T, Garg M, Lim SL, Madan V, Hattori N, Nagata Y, Miyano S, Yeoh AE, Hou HA, Jiang YY, Takao S, Liu LZ, Tan SZ, ..., Koeffler HP, et al.
  46. Outcome after neoadjuvant chemotherapy in Asian breast cancer patients. Cancer Med. 2017 Jan. 6(1):173-185. doi: 10.1002/cam4.985. Lim LY, Miao H, Lim JS, Lee SC, Bhoo-Pathy N, Yip CH, Taib NA, Chan P, Tan EY, Lim SH, Lim GH, Woo E, Tan YS, Lee JA, Wong M, Tan PH, Ong KW, Wong FY, Yap YS, Hartman M.
  47. Same admission laparoscopic cholecystectomy for acute cholecystitis: is the "golden 72 hours" rule still relevant? HPB (Oxford). 2017 Jan. 19(1):47-51. doi: 10.1016/j.hpb.2016.10.006. Tan JK, Goh JC, Lim JW, Shridhar IG, Madhavan K, Kow AW.
  48. Second malignant neoplasms in childhood cancer survivors treated in a tertiary paediatric oncology centre. Ann Acad Med Singapore. 2017 Jan. 46(1):11-19. Lim JW, Yeap FS, Chan YH, Yeoh AE, Quah TC, Tan PL.
  49. The conundrum in the diagnosis and management of atypical fulminant measles in a leukemia survivor on maintenance chemotherapy. J Pediatr Hematol Oncol. 2017 Jan. 39(1):e36-e38. Huang JG, Yeoh AE, Tambyah PA, Suhaila MI.
  50. Totally extra-peritoneal repair for acute incarcerated femoral hernia with intestinal obstruction. Int J Surg Case Rep. 2017 Jan. 32:16-18. doi: 10.1016/j.ijscr.2017.01.034. Kim G, Yan So JB, Shabbir A.
  51. Towards precision medicine in the clinic: From biomarker discovery to novel therapeutics. Trends Pharmacol Sci. 2017 Jan. 38(1):25-40. doi: 10.1016/j.tips.2016.10.012. Collins DC, Sundar R, Lim JS, Yap TA.
  52. Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1. Oncotarget. 2017 Feb 1. doi: 10.18632/oncotarget.15017. Wang L, Chan CE, Wong AL, Wong FC, Lim SW, Chinnathambi A, Alharbi SA, Lee LS, Soo R, Yong WP, Lee SC, Ho PC, Sethi G, Goh BC.
  53. Aberrant RNA splicing and mutations in spliceosome complex in acute myeloid leukemia. Stem Cell Investig. 2017 Feb 9. 4:6. doi: 10.21037/sci.2017.01.06. Zhou J, Chng WJ.
  54. Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation. Antioxid Redox Signal. 2017 Feb 10. 26(5):193-206. doi: 10.1089/ars.2016.6778. Cheah IK, Tang RM, Yew TS, Lim KH, Halliwell B.
  55. Integrative analyses of transcriptome sequencing identify novel functional lncRNAs in esophageal squamous cell carcinoma. Oncogenesis. 2017 Feb 13. 6(2):e297. doi: 10.1038/oncsis.2017.1. Li CQ, Huang GW, Wu ZY, Xu YJ, Li XC, Xue YJ, Zhu Y, Zhao JM, Li M, Zhang J, Wu JY, Lei F, Wang QY, Li S, Zheng CP, Ai B, Tang ZD, Feng CC, Liao LD, Wang SH, Shen JH, Liu YJ, ..., Koeffler HP, et al.
  56. Extent of field change in colorectal cancers with BRAF mutation. Singapore Med J. 2017 Feb 17. doi: 10.11622/smedj.2017012. Poh A, Chang HS, Tan KY, Sam XX, Khoo A, Choo SN, Nga ME, Wan WK.
  57. A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma. Oncotarget. 2017 Feb 21. 8(8):12831-12842. doi: 10.18632/oncotarget.14606. Dai X, Wang L, Deivasigamni A, Looi CY, Karthikeyan C, Trivedi P, Chinnathambi A, Alharbi SA, Arfuso F, Dharmarajan A, Goh BC, Hui KM, Kumar AP, Mustafa MR, Sethi G.
  58. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017 Feb 23. 542(7642):479-483. doi: 10.1038/nature21076. Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, ..., Koeffler HP, et al.
  59. A longitudinal exploration of the psychological resources influencing depression and anxiety in newly diagnosed Asian persons with cancer. Psychooncology. 2017 Feb. 26(2):278-281. doi: 10.1002/pon.4110. Lim HA, Griva K, Tan JY, Mahendran R.
  60. Biliary metastasis in colorectal cancer confers a poor prognosis: case study of 5 consecutive patients. Ann Hepatobiliary Pancreat Surg. 2017 Feb. 21(1):57-60. doi: 10.14701/ahbps.2017.21.1.57. Koh FH, Shi W, Tan KK.
  61. Extensive peritoneal lavage after curative gastrectomy for gastric cancer (EXPEL): study protocol of an international multicentre randomised controlled trial. Jpn J Clin Oncol. 2017 Feb. Kim G, Chen E, Tay AY, Lee JS, Phua JN, Shabbir A, So JB, Tai BC.
  62. Laparoscopic anterior resection with transvaginal specimen extraction (TVSE) for colorectal cancer and concomitant total hysterectomy and bilateral salpingo-oophrectomy (THBSO): A Technical Description. Ann Surg Oncol. 2017 Feb. 24(2):441. doi: 10.1245/s10434-016-5478-7. Tan CN, Chong CS, Fong YF, Rauff S, Tan KK.
  63. Perioperative blood transfusion: does it influence survival and cancer progression in metastatic spine tumor surgery? Transfusion. 2017 Feb. 57: 440–450. doi:10.1111/trf.13912. Zaw AS, Kantharajanna SB, Maharajan K, Tan B, Vellayappan B, Kumar N.
  64. Risk Factors for Mortality in Asian Children Admitted to the Paediatric Intensive Care Unit after Haematopoietic Stem Cell Transplantation. Ann Acad Med Singapore. 2017 Feb. 46(2):44-49. Santhanam H, Ong JS, Shen L, Tan PL, Koh PL.
  65. The Singapore Myeloma Study Group Consensus Guidelines for the management of patients with multiple myeloma. Singapore Med J. 2017 Feb. 58(2):55-71. doi: 10.11622/smedj.2016150. de Mel S, Chen Y, Gopalakrishnan SK, Ooi M, Teo C, Tan D, Teo ML, Tso AC, Lee LK, Nagarajan C, Goh YT, Chng WJ.
  66. Use of cryobiopsy during pleuroscopy for diagnosis of sarcomatoid malignant mesothelioma. Thorax. 2017 Feb. 72(2):193-195. doi: 10.1136/thoraxjnl-2016-208994. Chan HP, Liew MF, Seet JE, Lee P.
  67. Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP. Genome Res. 2017 Feb. 27(2):185-195. doi: 10.1101/gr.209163.116. Qian M, Zhang H, Kham SK, Liu S, Jiang C, Zhao X, Lu Y, Goodings C, Lin TN, Zhang R, Moriyama T, Yin Z, Li Z, Quah TC, Ariffin H, Tan AM, Shen S, Bhojwani D, Hu S, Chen S, Zheng H, Pui CH, ..., Yeoh AE, et al.
  68. Combining Molecularly Targeted Agents: Is More Always Better? Clin Cancer Res. 2017 Mar. 23(5):1123-1125. doi: 10.1158/1078-0432.CCR-16-2399. Sundar R, Valeri N, Harrington KJ, Yap TA.
  69. Mutational profiling of acute lymphoblastic leukemia with testicular relapse. J Hematol Oncol. 2017 Mar 2. 10(1):65. doi: 10.1186/s13045-017-0434-y. Ding LW, Sun QY, Mayakonda A, Tan KT, Chien W, Lin DC, Jiang YY, Xu L, Garg M, Lao ZT, Lill M, Yang H, Yeoh AE, Koeffler HP.
  70. BRCA2 hypomorphic missense variants confer moderate risks of breast cancer. Cancer Res. 2017 Mar 10. pii: canres.2568.2016. doi: 10.1158/0008-5472.CAN-16-2568. Shimelis H, …, Hartman M, …, Couch FJ et al.
  71. Carfilzomib and dexamethasone vs bortezomib and dexamethasone in patients with relapsed multiple myeloma: results of the phase 3 study ENDEAVOR (NCT01568866) according to age subgroup. Leuk Lymphoma. 2017 Mar 17. 1-4. doi: 10.1080/10428194.2017.1298755. Ludwig H, Dimopoulos MA, Moreau P, Chng WJ, Goldschmidt H, Hájek R, Facon T, Pour L, Niesvizky R, Oriol A, Rosiñol L, Suvorov A, Gaidano G, Pika T, Weisel K, Goranova-Marinova V, Palumbo A, Gillenwater HH, Mohamed N, Aggarwal S, Feng S, Joshua D.
  72. Intensity-modulated radiation therapy for early-stage breast cancer: is it ready for prime time? Breast Cancer (Dove Med Press). 2017 Mar 20. 9:177-183. doi: 10.2147/BCTT.S127583. Chan TY, Tan PW, Tang JI.
  73. Identification of a Novel SYK/c-MYC/MALAT1 Signaling Pathway and Its Potential Therapeutic Value in Ewing Sarcoma. Clin Cancer Res. 2017 Mar 23. doi: 10.1158/1078-0432.CCR-16-2185. Sun H, Lin DC, Cao Q, Pang B, Gae DD, Lee VKM, Lim HJ, Doan N, Said JW, Gery S, Chow M, Mayakonda A, Forscher C, Tyner JW, Koeffler HP.
  74. Exosomes in Cancer Nanomedicine and Immunotherapy: Prospects and Challenges. Trends Biotechnol. 2017 Mar 29. pii: S0167-7799(17)30040-9. doi: 10.1016/j.tibtech.2017.03.004. Syn NL, Wang L, Chow EK, Lim CT, Goh BC.
  75. Body image and emotional distress in newly diagnosed cancer patients: The mediating role of dysfunctional attitudes and rumination. Body Image. 2017 Mar. 20:58-64. doi: 10.1016/j.bodyim.2016.11.001. Liu J, Peh CX, Mahendran R.
  76. Clinics in diagnostic imaging (175). Corpus callosum glioblastoma multiforme (GBM): butterfly glioma. Singapore Med J. 2017 Mar. 58(3):121-125. doi: 10.11622/smedj.2017017. Krishnan V, Lim TC, Ho FC, Peh WC.
  77. Conversion Surgery Post-Intraperitoneal Paclitaxel and Systemic Chemotherapy for Gastric Cancer Carcinomatosis Peritonei. Are We Ready? J Gastrointest Surg. 2017 Mar. 21(3):425-433. doi: 10.1007/s11605-016-3336-3. Chan DY, Syn NL, Yap R, Phua JN, Soh TI, Chee CE, Nga ME, Shabbir A, So JB, Yong WP.
  78. Copy number analysis identifies tumor suppressive lncRNAs in human osteosarcoma. Int J Oncol. 2017 Mar. 50(3):863-872. doi: 10.3892/ijo.2017.3864. Xie J, Lin D, Lee DH, Akunowicz J, Hansen M, Miller C, Sanada M, Kato M, Akagi T, Kawamata N, Ogawa S, Koeffler HP.
  79. Development of a compact continuum tubular robotic system for nasopharyngeal biopsy. Med Biol Eng Comput. 2017 Mar. 55(3):403-417. doi: 10.1007/s11517-016-1514-9. Wu L, Song S, Wu K, Lim CM, Ren H.
  80. Diagnosis and relapse: cytogenetically normal acute myelogenous leukemia without FLT3-ITD or MLL-PTD. Leukemia. 2017 Mar. 31(3):762-766. doi: 10.1038/leu.2016.343. Chien W, Sun QY, Ding LW, Mayakonda A, Takao S, Liu L, Lim SL, Tan KT, Garg M, De Sousa Maria Varela A, Xiao J, Jacob N, Behrens K, Stocking C, Lill M, Madan V, Hattori N, Gery S, Ogawa S, Wakita S, Ikezoe T, Shih LY, ..., Koeffler HP, et al.
  81. Don't mistake it as a polyp! Gut. 2017 Mar. 66(3):553. doi: 10.1136/gutjnl-2016-312704. Tian-Zhi L, Leong Qi Hui F, Tan KK.
  82. Intraperitoneal chemotherapy for gastric cancer with peritoneal disease: experience from Singapore and Japan. Gastric Cancer. 2017 Mar. 20(Suppl 1):122-127. doi: 10.1007/s10120-016-0660-y. Kono K, Yong WP, Okayama H, Shabbir A, Momma T, Ohki S, Takenoshita S, So J.
  83. LIN28B Activation by PRL-3 Promotes Leukemogenesis and a Stem Cell-like Transcriptional Program in AML. Mol Cancer Res. 2017 Mar. 15(3):294-303. doi: 10.1158/1541-7786.MCR-16-0275-T. Zhou J, Chan ZL, Bi C, Lu X, Chong PS, Chooi JY, Cheong LL, Liu SC, Ching YQ, Zhou Y, Osato M, Tan TZ, Ng CH, Ng SB, Wang S, Zeng Q, Chng WJ.
  84. Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes. Nat Genet. 2017 Mar. 49(3):451-456. doi: 10.1038/ng.3772. de Rooij JD, Branstetter C, Ma J, Li Y, Walsh MP, Cheng J, Obulkasim A, Dang J, Easton J, Verboon LJ, Mulder HL, Zimmermann M, Koss C, Gupta P, Edmonson M, Rusch M, Lim JY, Reinhardt K, Pigazzi M, Song G, Yeoh AE, Shih LY, et al.
  85. Peripheral Nerve Lymphomatosis. J Hand Surg Asian Pac Vol. 2017 Mar. 22(1):104-107. doi: 10.1142/S0218810417720042. Foo TL, Yak R, Puhaindran ME.
  86. Preleukemia: one name, many meanings. Leukemia. 2017 Mar. 31(3):534-542. doi: 10.1038/leu.2016.364. Koeffler HP, Leong G.
  87. Quantitative 18F-fluorocholine positron emission tomography for prostate cancer: correlation between kinetic parameters and Gleason scoring. EJNMMI Res. 2017 Mar. 7(1):25. doi: 10.1186/s13550-017-0269-0. Schaefferkoetter JJD, Wang Z, Stephenson MC, Roy S, Conti M, Eriksson L, Townsend DW, Thamboo T, Chiong E
  88. Quantitative Accuracy and Lesion Detectability of Low-Dose (18)F-FDG PET for Lung Cancer Screening. J Nucl Med. 2017 Mar. 58(3):399-405. doi: 10.2967/jnumed.116.177592. Schaefferkoetter JD, Yan J, Sjöholm T, Townsend DW, Conti M, Tam JK, Soo RA, Tham I.
  89. Rivaroxaban for heparin-induced thrombocytopenia: adding to the evidence. Ann Hematol. 2017 Mar. 96(3):525-527. doi: 10.1007/s00277-016-2871-z. Ong SY, Chin YA, Than H, Tan CW, Yap ES, Wong WH, Ng HJ.
  90. Significance of immune checkpoint proteins in EGFR-mutant non-small cell lung cancer. Lung Cancer. 2017 Mar. 105:17-22. doi: 10.1016/j.lungcan.2017.01.008. Soo RA, Kim HR, Asuncion BR, Fazreen Z, Omar MF, Herrera MC, Yun Lim JS, Sia G, Soong R, Cho BC.
  91. Single-cell genomic profiling of acute myeloid leukemia for clinical use: A pilot study. Oncol Lett. 2017 Mar. 13(3):1625-1630. doi: 10.3892/ol.2017.5669. Yan B, Hu Y, Ban KHK, Tiang Z, Ng C, Lee J, Tan W, Chiu L, Tan TW, Seah E, Ng CH, Chng WJ, Foo R.
  92. Update on immune checkpoint inhibitors in gynecological cancers. J Gynecol Oncol. 2017 Mar. 28(2):e20. doi: 10.3802/jgo.2017.28.e20. Heong V, Ngoi N, Tan DS.
  93. Minimal residual disease-guided therapy in childhood acute lymphoblastic leukemia. Blood. 2017 Apr 6. 129(14):1913-1918. doi: 10.1182/blood-2016-12-725804. Campana D, Pui CH.
  94. Improved outcomes for myeloid leukemia of down syndrome: A report from the Children's Oncology Group AAML0431 trial. Blood. 2017 Apr 7. pii: blood-2017-01-764324. doi: 10.1182/blood-2017-01-764324. Taub JW, Berman JN, Hitzler JK, Sorrell AD, Lacayo NJ, Mast K, Head D, Raimondi S, Hirsch B, Ge Y, Gerbing RB, Wang YC, Alonzo TA, Campana D, Coustan-Smith E, Mathew P, Gamis AS.
  95. Imprecision in the era of precision medicine in non-small cell lung cancer. Front Med (Lausanne). 2017 Apr 10. 4:39. doi: 10.3389/fmed.2017.00039. Sundar R, Chenard-Poirier M, Collins DC, Yap TA.
  96. Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma. Mol Oncol. 2017 Apr 11. doi: 10.1002/1878-0261.12064. Kong LR, Tan TZ, Ong WR, Bi C, Huynh H, Lee SC, Chng WJ, Eichhorn PJA, Goh BC.
  97. Palliative radiotherapy for gastric cancer: a systematic review and meta-analysis. Oncotarget. 2017 Apr 11. 8(15):25797-25805. doi: 10.18632/oncotarget.15554. Tey J, Soon YY, Koh WY, Leong CN, Choo BA, Ho F, Vellayappan B, Lim K, Tham IW.
  98. A systematic review and meta-analysis of individual patient data on the impact of the BIM deletion polymorphism on treatment outcomes in epidermal growth factor receptor mutant lung cancer. Oncotarget. 2017 Apr 13. doi: 10.18632/oncotarget.17102. Soh SX, Siddiqui FJ, Allen JC, Kim GW, Lee JC, Yatabe Y, Soda M, Mano H, Soo RA, Chin TM, Ebi H, Yano S, Matsuo K, Niu X, Lu S, Isobe K, Lee JH, Yang JC, Zhao M, Zhou C, Lee JK, Lee SH, et al.
  99. Getting the first degree relatives to screen for colorectal cancer is harder than it seems - patients' and their first degree relatives' perspectives. Int J Colorectal Dis. 2017 Apr 13. doi: 10.1007/s00384-017-2818-4. Tan KK, Lim TZ, Chan DK, Chew E, Chow WM, Luo N, Wong ML, Koh GC.
  100. Whole-genome non-coding sequence analysis in T-cell acute lymphoblastic leukemia identifies oncogene enhancer mutations. Blood. 2017 Apr 13. pii: blood-2017-03-771162. doi: 10.1182/blood-2017-03-771162. Hu S, Qian M, Zhang H, Guo Y, Yang J, Zhao X, He H, Lu J, Pan J, Chang M, Du G, Lin TN, Kham SK, Quah TC, Ariffin H, Tan AM, Cheng Y, Li C, Yeoh AE, Pui CH, Skanderup AJ, Yang JJ.
  101. Significant effect of polymorphisms in CYP2D6 on response to tamoxifen therapy for breast cancer; A prospective multicenter study. Clin Cancer Res. 2017 Apr 15. 23(8):2019-2026. doi: 10.1158/1078-0432.CCR-16-1779. Zembutsu H, …, Hartman M, Chan CW, Lee SC, …, Nakamura Y et al.
  102. ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma. Oncogene. 2017 Apr 20. 36(16):2243-2254. doi: 10.1038/onc.2016.377. Hazawa M, Lin DC, Handral H, Xu L, Chen Y, Jiang YY, Mayakonda A, Ding LW, Meng X, Sharma A, Samuel S, Movahednia MM, Wong RW, Yang H, Tong C, Koeffler HP.
  103. The utility of flow cytometry in differentiating NK/T cell lymphoma from indolent and reactive NK cell proliferations. Cytometry B Clin Cytom. 2017 Apr 21. doi: 10.1002/cyto.b.21529. de Mel S, Li JB, Abid MB, Tang TPL, Tay HM, Ting WC, Poon LM, Chung TH, Mow B, Tso A, Ong KH, Chng WJ, Liu TC.
  104. Cutaneous plasmacytosis: A clinicopathologic study of a series of cases and their treatment outcomes. Am J Dermatopathol. 2017 Apr 25. doi: 10.1097/DAD.0000000000000907. Han XD, Lee SSJ, Tan SH, Chong WS, Ng SK, Ooi MGM, Goh CL.
  105. LPS independent activation of the pro-inflammatory receptor Trem1 by C/EBPε in granulocytes. Sci Rep. 2017 Apr 25.7:46440. doi: 10.1038/srep46440. Suh HC, Benoukraf T, Shyamsunder P, Yin T, Cao Q, Said J, Lee S, Lim R, Yang H, Salotti J, Johnson PF, Madan V, Koeffler HP.
  106. BCL6 promotes glioma and serves as a therapeutic target. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3981-3986. doi: 10.1073/pnas.1609758114. Xu L, Chen Y, Dutra-Clarke M, Mayakonda A, Hazawa M, Savinoff SE, Doan N, Said JW, Yong WH, Watkins A, Yang H, Ding LW, Jiang YY, Tyner JW, Ching J, Kovalik JP, Madan V, Chan SL, Müschen M, Breunig JJ, Lin DC, Koeffler HP.
  107. Laparoscopic surgery should be considered in T4 colon cancer. Int J Colorectal Dis. 2017 Apr. 32(4):517-520. doi: 10.1007/s00384-016-2702-7. Chan DK, Tan KK.
  108. Long-term renal outcome after allogeneic hemopoietic stem cell transplant: A comprehensive analysis of risk factors in an Asian patient population. Clin Transplant. 2017 Apr. 31(4). doi: 10.1111/ctr.12920. Zhou W, Sultana R, Diong C, Goh YT, Gopalakrishnan S, Ho A, Hwang W, Koh LP, Koh M, Loh Y, Tan P, Linn YC.
  109. Metastatic breast cancer to the rectum: A case report with emphasis on MRI features. Medicine (Baltimore). 2017 Apr. 96(17):e6739. doi: 10.1097/MD.0000000000006739. Lau LC, Wee B, Wang S, Thian YL.
  110. Obscure bleeding from an ovarian carcinoma invading the small bowel. Am J Gastroenterol. 2017 Apr. 112(4):534. doi: 10.1038/ajg.2016.545. Heidi CS, Chan DK, Solomon M, Tan KK.
  111. Predicting clinical outcomes using proteomics in non-small cell lung cancer - The past, present, and future. J Thorac Oncol. 2017 Apr. 12(4):602-606. doi: 10.1016/j.jtho.2017.01.025. Soo RA, Adjei AA.
  112. Psychosocial concerns of cancer patients in Singapore. Asia Pac J Clin Oncol. 2017 Apr. 13(2):e96-e103. doi: 10.1111/ajco.12344. Mahendran R, Lim HA, Chua J, Lim SE, Kua EH.
  113. Role of (18)F-FDG PET/CT in the diagnosis and management of multiple myeloma and other plasma cell disorders: a consensus statement by the International Myeloma Working Group. Lancet Oncol. 2017 Apr. 18(4):e206-e217. doi: 10.1016/S1470-2045(17)30189-4. Cavo M, Terpos E, Nanni C, Moreau P, Lentzsch S, Zweegman S, Hillengass J, Engelhardt M, Usmani SZ, Vesole DH, San-Miguel J, Kumar SK, Richardson PG, Mikhael JR, da Costa FL, Dimopoulos MA, Zingaretti C, Abildgaard N, Goldschmidt H, Orlowski RZ, Chng WJ, Einsele H, et al.
  114. Roux-en-Y or Billroth II reconstruction after radical distal gastrectomy for gastric cancer: A multicenter randomized controlled trial. Annals of Surgery. 2017 Apr. So JB, Rao J, Wong AS, Chan YH, Pang NQ, Tay AY, Yung MY, Su Z, Phua JN, Shabbir A, Ng E.
  115. Surgery for gastrointestinal stromal tumours in Australia and New Zealand: Results from a bi-national audit. ANZ J Surg. 2017 Apr. 87(4):220-221. doi: 10.1111/ans.13840. Parameswaran R, Roberts RH, Brown WA, Aly A, Kiroff G, Epari K, MacCormick AD, Thomson IG, Thompson SK.
  116. The KEY to the end of chemotherapy in non-small cell lung cancer? Ann Transl Med. 2017 Apr. 5(7):166. doi: 10.21037/atm.2017.03.55. Huang Y, Soo RA.
  117. Thyroid cytology-nuclear versus architectural atypia within the "Atypia of undetermined significance/follicular lesion of undetermined significance" Bethesda category have significantly different rates of malignancy. Cancer. 2017 Apr. 125(4):245-256. doi: 10.1002/cncy.21823. Gan TR, Nga ME, Lum JH, Wong WM, Tan WB, Parameswaran R, Ngiam KY.
  118. Evaluating genetic variants associated with breast cancer risk in high and moderate-penetrance genes in Asians. Carcinogenesis. 2017 May 1. 38(5):511-518. doi: 10.1093/carcin/bgx010. Han MR, …, Hartman M, …, Long J.
  119. Genomic and Epigenomic Heterogeneity of Hepatocellular Carcinoma. Cancer Res. 2017 May 1. 77(9):2255-2265. doi: 10.1158/0008-5472.CAN-16-2822. Lin DC, Mayakonda A, Dinh HQ, Huang P, Lin L, Liu X, Ding LW, Wang J, Berman BP, Song EW, Yin D, Koeffler HP.
  120. Management of epidermal growth factor receptor tyrosine kinase inhibitor-related cutaneous and gastrointestinal toxicities. Asia Pac J Clin Oncol. 2017 May 2. doi: 10.1111/ajco.12687. Aw DC, Tan EH, Chin TM, Lim HL, Lee HY, Soo RA.
  121. Risk of death from cardiovascular disease following breast cancer in Southeast Asia: A prospective cohort study. Sci Rep. 2017 May 2. 7(1):1365. doi: 10.1038/s41598-017-01540-7. Gernaat SAM, Ho PJ, Rijnberg N, Lee SC, Lim SH, Yap YS, Grobbee DE, Hartman M, Verkooijen HM.
  122. Risk of death from cardiovascular disease following breast cancer: A systematic review. Breast Cancer Res Treat. 2017 May 13. doi: 10.1007/s10549-017-4282-9. Gernaat SAM, Ho PJ, Rijnberg N, Emaus MJ, Baak LM, Hartman M, Grobbee DE, Verkooijen HM.
  123. Breast reconstruction rate and profile in a Singapore patient population: a National University Hospital experience. Singapore Med J. 2017 May 15. doi: 10.11622/smedj.2017035.  Sim N, Soh S, Ang CH, Hing CH, Lee HJ, Nallathamby V, Yap YL, Ong WC, Lim TC, Lim J. 
  124. Evolution in treatment strategy for metastatic spine disease: Presently evolving modalities. Eur J Surg Oncol. 2017 May 17. pii: S0748-7983(17)30484-5. doi: 10.1016/j.ejso.2017.05.006. Kumar N, Malhotra R, Zaw AS, Maharajan K, Naresh N, Kumar A, Vellayappan B.
  125. Young colorectal cancer patients often present too late. Int J Colorectal Dis. 2017 May 18. doi: 10.1007/s00384-017-2837-1. Law JH, Koh FH, Tan KK.
  126. Super-enhancers and broad H3K4me3 domains form complex gene regulatory circuits involving chromatin interactions. Sci Rep. 2017 May 19. 7(1):2186. doi: 10.1038/s41598-017-02257-3. Cao F, Fang Y, Tan HK, Goh Y, Choy JYH, Koh BTH, Hao Tan J, Bertin N, Ramadass A, Hunter E, Green J, Salter M, Akoulitchev A, Wang W, Chng WJ, Tenen DG, Fullwood MJ.
  127. The EMT spectrum and therapeutic opportunities. Mol Oncol. 2017 May 24. doi: 10.1002/1878-0261.12082. Voon DC, Huang RY, Jackson RA, Thiery JP.
  128. Advances in the development of molecularly targeted agents in non-small-cell lung cancer. Drugs. 2017 May. 77(8):813-827. doi: 10.1007/s40265-017-0732-2. Dolly SO, Collins DC, Sundar R, Popat S, Yap TA.
  129. Clinical risk stratification in patients with surgically resectable micropapillary bladder cancer. BJU Int. 2017 May. 119(5):684-691. doi: 10.1111/bju.13689. Fernandez MI, Williams SB, Willis DL, Slack RS, Dickstein RJ, Parikh S, Chiong E, Siefker-Radtke AO, Guo CC, Czerniak BA, McConkey DJ, Shah JB, Pisters LL, Grossman HB, Dinney CP, Kamat AM.
  130. Nationwide multi-institutional retrospective analysis of high-dose-rate brachytherapy combined with external beam radiotherapy for localized prostate cancer: An Asian Prostate HDR-BT Consortium. Brachytherapy. 2017 May - Jun. 16(3):503-510. doi: 10.1016/j.brachy.2017.01.006. Ishiyama H, Kamitani N, Kawamura H, Kato S, Aoki M, Kariya S, Matsumura T, Kaidu M, Yoshida K, Hashimoto Y, Noda Y, Lim KHC, Kawase T, Takahashi T, Inaba K, Kumano M, Yoshikawa N, Yoshioka Y, Nakamura K, Hiratsuka J, Itami J, Hayakawa K.
  131. Prospective validation of %p2PSA and the prostate health index, in prostate cancer detection in initial prostate biopsies of Asian men, with total PSA 4-10 ng ml-1. Asian J Androl. 2017 May-Jun. 19(3):286-290. doi: 10.4103/1008-682X.168687. Tan LG, Tan YK, Tai BC, Tan KM, Gauhar V, Tiong HY, Hawkins RC, Thamboo TP, Hong FS, Chiong E.
  132. Quality of life of family caregivers of cancer patients in Singapore and globally. Singapore Med J. 2017 May. 58(5):258-261. doi: 10.11622/smedj.2016083. Lim HA, Tan JY, Chua J, Yoong RK, Lim SE, Kua EH, Mahendran R.
  133. Real time near-infrared Raman spectroscopy for the diagnosis of nasopharyngeal cancer. Oncotarget. 2017 May 8. doi: 10.18632/oncotarget.17703. Ming LC, Gangodu NR, Loh T, Zheng W, Wang J, Lin K, Zhiwei H.
  134. Response to Re: Bacteriological study in perianal abscess is not useful and not cost-effective. ANZ J Surg. 2017 May. 87(5):421. doi: 10.1111/ans.13972. Xu R, Tan KK, Chong CS.
  135. Upregulation of thioredoxin-1 in activated human NK cells confers increased tolerance to oxidative stress. Cancer Immunol Immunother. 2017 May. 66(5):605-613. doi: 10.1007/s00262-017-1969-z. Mimura K, Kua LF, Shimasaki N, Shiraishi K, Nakajima S, Siang LK, Shabbir A, So J, Yong WP, Kono K.
  136. Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium. Diabetologia. 2017 Jun. 60(6):1022-1032. doi: 10.1007/s00125-017-4229-z. Chen Y, Wu F, Saito E, Lin Y, Song M, Luu HN, Gupta PC, Sawada N, Tamakoshi A, Shu XO, Koh WP, Xiang YB, Tomata Y, Sugiyama K, Park SK, Matsuo K, Nagata C, Sugawara Y, Qiao YL, You SL, Wang R, Shin MH, ..., Chia KS, et al.
  137. Endoscopic stenting does not worsen long term outcomes amongst patients presenting with obstruction from colorectal cancers. Ann Surg Oncol. 2017 Jun. 24(6):1618-1625. doi: 10.1245/s10434-016-5724-z. Lim TZ, Chan DK, Tan KK.
  138. Epigenomic Promoter Alterations Amplify Gene Isoform and Immunogenic Diversity in Gastric Adenocarcinoma. Cancer Discov. 2017 Jun. 7(6):630-651. doi: 10.1158/2159-8290.CD-16-1022. Qamra A, Xing M, Padmanabhan N, Kwok JJT, Zhang S, Xu C, Leong YS, Lee Lim AP, Tang Q, Ooi WF, Suling Lin J, Nandi T, Yao X, Ong X, Lee M, Tay ST, Keng ATL, Gondo Santoso E, Ng CCY, Ng A, Jusakul A, Smoot D, ..., Yeoh KG, et al.