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Dr Dedrick Chan

Designations:
  • Consultant, Division of Colorectal Surgery, Department of Surgery, National University Hospital
  • Consultant, Division of Surgical Oncology, National University Cancer Institute, Singapore
  • Consultant, Division of Colorectal Surgery, Department of Surgery, Alexandra Hospital
Qualifications:
MBBS(Singapore), MMed (Surgery), MCI, PhD (Oxford), FRCS(England)
Specialties:
Surgery, Surgical Oncology
Sub-Specialties:
Colorectal Surgery
Special Interests:
​Oncologic surgery, minimally invasive approaches, colonoscopy

Biosketch

​Dr Dedrick Chan attained specialist registration in General Surgery in 2018, and is currently a Consultant with the Division of Colorectal Surgery at the National University Hospital.

As a Clinician-Scientist, Dedrick investigates the molecular underpinnings of colorectal cancer, and aims to translate novel findings uncovered in the laboratory to tangible improvements in cancer outcomes for patients. Dedrick is a Junior Academic Fellow with the Department of Surgery, Yong Loo Lin School of Medicine. He completed a PhD at the University of Oxford in 2023, and was funded by a National Medical Research Council Research Training Fellowship.

Dedrick's clinical interest and research focus revolves around colorectal cancer. As a colorectal surgeon, Dedrick introduces surgically-oriented interventions which improve cancer outcomes and the patient experience. Dedrick's research builds on this clinical work, and has implications for cancer intiation, proliferation and metastasis. He seeks to understand the role which somatic driver mutations play in phenotypically normal tissue. 

Dedrick also studies the cooperative and competitive interplay between clonal populations in heterogeneous cancer tissue.

Awards

  • 2023 - Flashtalk Winner, 10th Annual CRUK-Oxford Centre Symposium
  • 2023 - N2CR-CSDU Career Development Fellow
  • 2020 - NMRC Research Training Fellowship (Full-time Overseas PhD)
  • 2018 - ExxonMobil Research Fellowship for Clinicians

Journals & Publications

  1. ​Ng AS, Chan DKH. Commonalities and differences in the mutational signature and somatic driver mutation landscape across solid and hollow viscus organs. Oncogene. 2023 Sep;42(37):2713-2724.
  2. Chan DKH, Mandal A, Hester S, Yu Z, Higgins GS, Kessler BM, Fischer R, Buczacki SJA. Biallelic FBXW7 knockout induces AKAP8-mediated DNA damage in neighbouring wildtype cells. Cell Death Discov. 2023 Jun 29;9(1):200.
  3. Chan DKH, Collins SD, Buczacki SJA. Generation and immunofluorescent validation of gene knockouts in adult human colonic organoids using multi-guide RNA CRISPR-Cas9. STAR Protoc. 2023 Jan 3;4(1):101978.
  4. Chan DKH, Buczacki SJA. Stage migration - a negative quality indicator in colon cancer management. Colorectal Dis. 2022 Feb;24(2):153-154.
  5. Lal N, Chan DKH, Ng ME, Vermeulen L, Buczacki SJA. Primary tumour immune response and lymph node yields in colon cancer. Br J Cancer. 2022 May;126(8):1178-1185.
  6. Chan DKH, Buczacki SJA. Tumour heterogeneity and evolutionary dynamics in colorectal cancer. Oncogenesis. 2021 Jul 16;10(7):53.
  7. Tan JKH, Ang JJ, Chan DKH. Enhanced recovery program versus conventional care after colorectal surgery in the geriatric population: a systematic review and meta-analysis. Surg Endosc. 2021 Jun;35(6):3166-3174.
  8. Ang JJ, Chia DKA, Chan DKH. Lymphocyte-White Cell Ratio Is a Novel Marker of Morbidity Following Colorectal Cancer Surgery. J Surg Res. 2021 Mar;259:71-78.
  9. Chan DKH, Lee SKF, Ang JJ. Indocyanine green fluorescence angiography decreases the risk of colorectal anastomotic leakage: Systematic review and meta-analysis. Surgery. 2020 Dec;168(6):1128-1137.
  10. Chan DKH, Tan KK. Stenting versus surgery in obstructed malignant colorectal cancer-a review of short and long-term results. J Gastrointest Oncol. 2020 Jun;11(3):486-490. 

Professional Memberships

  • ​Fellow, Royal College of Surgeons of England
  • Associate Member, American Association for Cancer Research
  • Member, American Society of Colon and Rectal Surgeons