SharePoint
A- A A+

For Patients & Visitors

Find a Doctor

Find a Doctor

Associate Professor Ng Siok Bian

Photo of Associate Professor Ng Siok Bian
Credential:
MBBS (S'pore), FRCPA (Australia)
Designation:
Senior Consultant, Department of Pathology, National University Hospital
Senior Consultant, National University Cancer Institute, Singapore
Associate Professor, Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore (NUS)
Principal Associate, Cancer Science Institute of Singapore, NUS
Visiting Senior Consultant, Khoo Teck Puat Hospital, Singapore
Specialty:
Cancer, Pathology
Medical and Surgical Conditions:
Blood Cancer, Leukaemia, Lymphoma, Multiple Myeloma, Myelodysplastic Syndrome (MDS), Myeloproliferative Neoplasms (MPN)
Special Interest:
Haematolymphoid pathology
EBV-related lymphoproliferative disease
Institution:
National University Hospital
National University Cancer Institute, Singapore
National University Health System
A/Prof Ng Siok Bian obtained her medical degrees from National University of Singapore and obtained Fellowship of the Royal College of Pathologists of Australasia in 2002. She subsequently completed her specialty training in haematolymphoid pathology as a visiting fellow at National Cancer Institute / National Institute of Health, Bethesda, USA, under the supervision of Dr ES Jaffe. A/Prof Ng joined the department of Pathology, NUS in 2007. She is currently the research director of the department of Pathology in National University Health System (NUHS).
A/Prof Ng’s diagnostic expertise is in haematolymphoid pathology and molecular pathology. Her research focus is on lymphomas, in particular EBV-associated T/NK-cell lymphomas, using a combinational analytical approach via gene and miRNA expression profiling on paraffin embedded tissue samples. Her group also has expertise in quantitative immunofluorescence using multispectral imaging platform.

Professional Memberships

 

European Society of Haematopathology
Society of Haematopathology
Fellowship of Royal College of Pathologists of Australasia
United States and Canadian Academy of Pathologists 
National Healthcare Group Domain Specific Ethics Review Board

Research and Publications

  1. Selvarajan V, Osato M, Nah GSS, Yan J, Chung TH, Voon DC, Ito Y, Ham MF, Salto-Tellez M, Shimizu N, Choo SN, Fan S, Chng WJ, Ng SB. RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC. Leukemia. 2017 Oct;31(10):2219-2227
  2. Ng SB, Ohshima K, Selvarajan V, Huang G, Choo SN, Miyoshi H, Wang S, Chua HC, Yeoh A, Quah TC, Koh LP, Tan PL, Chng WJ. Prognostic implication of morphology, cyclinE2 and proliferation in EBV-associated T/NK lymphoproliferative disease in non-immunocompromised hosts. Orphanet J Rare Dis. 2014 Dec 5;9:165.
  3. Ng SB, Ohshima K, Selvarajan V, Huang G, Choo SN, Miyoshi H, Shimizu N, Reghunathan R, Chua HC, Yeoh AE, Quah TC, Koh LP, Tan PL, Chng WJ. EBV-associated T/NK-cell lymphoproliferative disorder in children and young adults has similar molecular signature to extranodal nasal NK/T-cell lymphoma but shows distinctive stem cell-like phenotype. Leuk Lymphoma. 2015 Aug;56(8):2408-15.
  4. Yan J*, Ng SB*, Tay JL, Lin B, Koh TL, Tan J, Selvarajan V, Liu SC, Bi C, Wang S, Choo SN, Shimizu N, Huang G, Yu Q, Chng WJ. EZH2 overexpression in natural killer /T-cell lymphoma confers growth advantage independently of histone methyltransferase activity. Blood. 2013 May 30;121(22):4512-20.
  5. Ng SB, Yan J, Huang G, Selvarajan V, Tay JL, Lin B, Bi C, Tan J, Kwong YL, Shimizu N, Aozasa K, Chng WJ. Dysregulated microRNAs affect pathways and targets of biological relevance in nasal-type natural killer/T-cell lymphoma. Blood. 2011 Nov 3;118(18):4919-29.
  6. Ng SB, Selvarajan V, Huang G, Zhou J, Feldman AL, Law M, Kwong YL, Shimizu N, Kagami Y, Aozasa K, Salto-Tellez M, Chng WJ. Activated Oncogenic Pathways and Therapeutic Targets in Extranodal Nasal-Type NK/T Cell Lymphoma Revealed by Gene Expression Profiling. J Pathol. 2011 Mar;223(4):496-510.
  7. Ng SB, Khoury JD. Epstein-Barr Virus in Lymphoproliferative Processes: An update for the diagnostic pathologist. Adv Anat Pathol 2009 Jan; 16(1):40-55. [IF-3.476; Cited 10 times]
  8. Ng SB, Lee V, Das K, Salto-Tellez M. The relevance of molecular diagnostics in the practice of surgical pathology. Expert Opin. Med. Diagn. (2008) 2(11):1401-14.
  9. Ng SB, Lai KW, Murugaya S, Lee KM, Loong SL, Fook-Chong S, Tao M, Sng I. Nasal-type extranodal natural killer/T-cell lymphomas: a clinicopathologic and genotypic study of 42 cases in Singapore. Mod Pathol 2004;17(9):1097-1107.