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Associate Professor Allen Yeoh Eng Juh

Photo of Associate Professor Allen Yeoh Eng Juh
Credential:
MBBS, MMed (Paediatrics)
Designation:
Head & Senior Consultant, Division of Paediatric Haematology and Oncology, Department of Paediatrics, Khoo Teck Puat - National University Children's Medical Institute, National University Hospital
Head & Senior Consultant, Division of Paediatric Haematology and Oncology, National University Cancer Institute, Singapore


Associate Professor, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore (Research Specialty: Haematology, Oncology & Blood/Marrow Transplantation)

Viva-Goh Foundation Associate Professor​

Specialty:
Paediatrics
Sub Specialty:
Paediatric Blood and Marrow Transplantation (BMT) Programme, Paediatric Haematology-Oncology
Medical and Surgical Conditions:
Childhood Leukaemia, Haemophilia (Children), Neutropenic Fever (Children)
Special Interest:
Pharmacogenomics in childhood leukemias
Treatment-related toxicities in childhood leukemias
Institution:
National University Hospital
National University Cancer Institute, Singapore
National University Health System
Associate Professor Allen Yeoh is the Head and Senior Consultant in the Division of Paediatric Haematology and Oncology of the NCIS and NUH, as well as Associate Professor in the Yong Loo Lin School of Medicine, NUS. He was trained in NUS and NUH and was in the St Jude Children's Research Hospital as a Clinical Fellow from 1999 to 2001.

A/Prof Yeoh's interest is in childhood leukaemia. He is currently the principal investigator of the multi-centre Malaysia-Singapore ALL and AML trials competitively funded by NMRC and A*STAR/Singapore Cancer Syndicate. Currently, these trials have been highly successful with >80% and >60% projected cure. He is the first Singaporean doctor to receive the American Society of Haematology Merit Award for his pioneering work in gene expression profiling in leukaemia. This work was one of the highest cited article in this field in 2003.

A/Prof Yeoh is also the recipient of numerous National and International Awards including the Singapore Youth Award 2002, the NUS Office of Life Sciences Award 2002, the Asian Innovation Award (Gold) 2003, the NMRC-BMRC Clinician Scientist Award from 2005 to date, the NUHS-Mokhtar Riady Pinnacle Award 2013 (Translational Research Innovator Award) and the National Medical Excellence Awards 2014 (National Outstanding Clinician Scientist Award).

Education and Fellowships
MBBS (NUS), MMed in Paediatrics (NUS), Clinical and research Fellowship programme in St Jude Children’s Research Hospital, Registrarship (Fellowship) programme in NUH, Residency traineeship position in the Department of Paediatrics, NUH

 
Grants:
As Principle Investigator
  • 2011 – 2013: Paired pre and post treatment whole genome gene expression profiling of bone marrow as a diagnostic and novel prognostic tool for treatment of childhood acute lymphoblastic and myeloid leukaemias – a Malaysia-Singapore study proposal
    • Funding Agency: NMRC
  • 2010 – 2012: Improving Medication Safety in Childhood Cancer through the use of Health Information Technology – a Paediatric Oncology Group (Singapore)
    • Funding Agency: HQI2F
  • 2010 – 2012: Pharmacogenomics in Childhood Acute Lymphoblastic Leukaemia
    • Funding Agency: NMRC
  • 2009 – 2016: Leukaemia Tissue Bank
    • Funding Agency: Cancer Singapore Institute
  • 2008 – 2011: Establishing New Capabilities for High Risk Leukaemia in Adult & Children Using Cell-based and Novel Drug Therapies
    • Funding Agency: Singapore Cancer Syndicate
  • 2008 – 2011: Pre-immunisation of parental stem cell donors against leukaemia-specific mutations/SNPs for adoptive transfer (PARENTS against LEUKAEMIA)
    • Funding Agency: Life Science Institute
  • 2008 – 2013: A multi-centre, multi-faceted therapeutic study incorporating whole genome association and candidate pathway studies for pharmacovigilance and toxico genomics in childhood acute lymphoblastic leukaemia: Malaysia-Singapore ALL 2008 study
    • Funding Agency: NMRC

Awards and Honours

  • NMRC Clinician Scientist Award (Senior Investigator Category), 2008
  • National University of Singapore, Faculty Research Excellence Award, AY2007/2008
  • National University of Singapore, Faculty Research Excellence Award, AY2006/2007
  • National Medical Research Council/Biomedical Research Council. Clinician Scientist Investigator Award, Category B/junior (Awarded by NMRC/A*STAR)
  • Asian Innovation Award (Gold, First Prize), 2003. (Awarded by the Far East Economic Review and Singapore Economic Development Board)
  • Singapore Youth Award for Science and Technology, 2002. (Awarded by the National Youth Council, Singapore) 
  • NUH Citation Awards Singapore, 2002 and 2003
  • NUH Long Service Award, Singapore, 2002
  • NUH Chairman of Medical Board Merit Award, Singapore, 2002.
  • NUS Office of Life Science and BMRC Young Investigator Award, Singapore, 2002.
  • Henry Neustein Award for the best research presentation in Society of Pediatric Pathology, Memphis, TN, USA, 2001.
  • American Society of Hematology Merit Award for the best research abstract in the category of Post-doctoral Fellow Research, Orlando, Florida, USA, 2001.
  • National Medical Council Totaliser Board Scholarship, 2001.
  • China Medical Board Scholarship to St Jude Children’s Research Hospital, 2000.
  • National Medical Research Council Protected Research Time to St Jude Children’s Research Hospital (USA), 1999.
  • Japan Society for Promotion of Science Scholarship for a one-month clinical/research attachment in Paediatric Bone Marrow Transplantation and Paediatric Oncology, 1998
  • Singapore-Malaysia Congress of Medicine Young Investigator Award in the 30th SMC, 1996

Professional Memberships

  • International member, American Society of Hematology (ASH)
  • Director, Singapore Cord Blood Bank Limited (SCBB)
  • Member of the Editorial Board for Pediatric Blood & Cancer
  • Director of the St Jude-Viva Children Cancer Programme
  • Paediatric Oncology Group of Singapore
  • Member of the Training and Education Fund, National University Cancer Institute, Singapore (NCIS)
  • Viva Foundation, Viva Children’s Cancer Program Director
  • Scientific Chairman of St Jude Viva Forum
  • Member of the Medical Advisory Board, Viva Foundation for Children with Cancer
  • Symposium Chairs for the SARS, Cancer, Paediatric and Chairman’s Symposia 
  • Member of Medical Advisory Board, Children’s Cancer Foundation

Research and Publications

  1. ​Lazaro AM, Xiao Y, Masaberg C, Hwang WY, Yeoh AE, Weiyan Y, Ng J, Hurley CK, Posch PE. Novel HLA class I and II alleles identified during routine registry typing. Tissue Antigens,2011 Jul 5
  2. Jiang N, Kham SK, Koh GS, Suang Lim JY, Ariffin H, Chew FT, Yeoh AE. Identification of prognostic protein biomarkers in childhood acute lymphoblastic leukemia (ALL). J Proteomics. 2011 May 16;74(6):843-57. Epub 2011 Mar 21.
  3. Chan, J.Y-S., Ugrasena, D.G., Lum, D.W-K., Lu, Y. and Yeoh, A.E-J. Xenobiotic and folate pathway gene polymorphisms and risk of childhood acute lymphoblastic leukaemia in Javanese children. Hematological Oncology, 2010 Sep 7
  4. Leong SM, Tan BX, Bte Ahmad B, Yan T, Chee LY, Koh LP, Yeoh AE, Koay ES, Mok YK, Lim TM. Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition. Blood. 2010 Oct 28:116(17):3286-96.
  5. Kham SK, Soh CK, Aw DC, Yeoh AE. TPMT*26 (208F-->L), a novel mutation detected in a Chinese. Br J Clin Pharmacol. 2009 Jul;68(1):120-3.
  6. Lazaro AM, Hwang WY, Yeoh AE, Ng J, Posch PE. Characterization of new HLA-B and -DRB1 alleles from Singapore. Tissue Antigens 2009 Jan;73(1):75-6.
  7. Kham SK, Soh CK, Liu TC, Chan YH, Ariffin H, Tan PL, Yeoh AE. Thiopurine S-methyltransferase activity in three major Asian populations: a population-based study in Singapore. Eur J Clin Pharmacol 2008 Apr;64(4):373-9.
  8. Ariffin H, Chen SP, Kwok CS, Quah TC, Lin HP, Yeoh AE. Ethnic differences in the frequency of subtypes of childhood acute lymphoblastic leukemia; results of the Malaysia-Singapore Leukemia Study Group. J Pediatr Hematol Oncol.2007 Jan;29(1):27-31
  9. Tan RM, Quah TC, Aung L, Liang S, Kirk RC, Yeoh AE. Improved outcome in childhood acute myeloid leukemia in Singapore with the MRC AML 10 protocol. Pediatr Blood Cancer, 2007 Mar, 48(3): 262-7
  10. Kwok CS, Kham SK, Ariffin H, Lin HP, Quah TC, Yeoh AE. Minimal residual disease (MRD) measurement as a tool to compare the efficacy of chemotherapeutic drug regimens using Escherichia Coli-asparaginase or Erwinia-asparaginase in childhood acute lymphoblastic leukemia (ALL). Pediatr Blood Cancer, 2006 Sep:47(3):299-304
  11. Lu Yi, Kham SK, Tan PL, Quah TC, Heng CK, Yeoh AE. Arrayed primer extension: a robust and reliable genotyping platform for the diagnosis of single gene disorders: beta-thalassemia and thiopurine methyltransferase deficiency. Genet Test. 2005 Fall;9(3):212-9.
  12. Chng WJ, Yeoh AE, Liu TC, Quah TC. t(8;14) Mature B-cell (Burkitt's) lymphoma/leukaemia with atypical morphology in a paediatric patient. Eur J Haematol. 2004 Nov;73(5):386-7.
  13. Li J, Liu H, Downing JR, Yeoh AE, Wong L. Simple rules underlying gene expression profiles of more than six subtypes of acute lymphoblastic leukemia (ALL) patients. Bioinformatics 2003 Jan;19(1):71-8.
  14. Yeoh AEJ, Ross ME, Shurtleff S, et al. Classification, Subtype Discovery and Prediction of Outcome in Pediatric Acute Lymphoblastic Leukemia by Gene Expression Profiling. Cancer Cell, 2002; 1(2): 133-43.
  15. Yeoh AEJ, Cunningham J, Yee GC, Houston JA, Richardson SL, Stewart CF, Houghton P, Bowman L, Gajjar A. Topotecan-filgrastim combination is an effective regimen for mobilizing peripheral blood stem cells. Bone Marrow Transplant 2001; 28(6): 563-71.
  16. Downing J, Higuchi M, Lenny N, Yeoh AEJ. Alterations in the AML-1 transcription factor in human leukemia. Sem in Cell and Developmental Biol, 2000; 11: 347-60.
  17. How HK, Yeoh A, Quah TC, Oh Y, Rosenfeld OG, Lee KO. Insulin-like growth factor binding proteins (IGFBPs) and IGFBP-related protein 1-levels in cerebrospinal fluid of children with acute lymphoblast leukemia. J Clin Endocrinol Metab. 1999;84:1283-7.
  18. Yeoh AEJ, Quah TC. Minimal residual disease in childhood acute lymphoblastic leukemia – an Asian perspective. J Am Med Assoc (South East Asia Ed), 1998:14:9.
  19. Quah TC, Sun L, Chew FT, Yeoh AEJ, Lee BW. Survival of childhood leukaemia in Singapore. Med Pediatr Oncol, 1996:26:318.
  20. Pek JH, Chan YH, Yeoh AE, Quah TC, Tan PL, Aung L. Health-related quality of life in children with cancer undergoing treatment: a first look at the Singapore experience. Ann Acad Med Singapore. 2010 Jan;39(1):43-8.
  21. Aung L, Chan YH, Yeoh EJ, Tan PL, Quah TC. Retinoblastoma: a recent experience at the National University Hospital, Singapore. Ann Acad Med Singapore. 2009 Aug;38(8):693-8.
  22. Hany Ariffin, S P Chen, H-L Wong, A Yeoh. Validation of a Multiplex RT-PCR Assay for Screening Significant Oncogene Fusion Transcripts in Children with Acute Lymphoblastic Leukaemia Singapore Med J 2003 Vol 44(10) : 517-520
  23. Quah TC, Yeoh AEJ, Sun L. Autologous bone marrow transplantation in a child with acute promyelocytic leukemia in second remission. Singapore Med J. 1997 Aug;38(8):344-6.
  24. Arrifin H, Chen SP, Wong HL, Yeoh AEJ. Validation of a multiplex RT-PCR assay for screening significant oncogene fusion transcripts in children with acute lymphoblastic leukaemia. Singapore Med J. 2003 Oct;44(10):517-20.
  25. Yeoh AEJ, Connett G. Recent advances in the management of childhood asthma. J Singapore Paediatr Soc, 1994;36:16-28.