The Division of Paediatric Haematology-Oncology delivers care in the Viva-University Children's Cancer Centre (VUC3) for young cancer patients with all malignant conditions ranging from leukaemias to solid tumours.
The Division is also exceedingly active in translational clinical research. The Division has been leading the highly successful multi-centre Malaysia-Singapore ALL studies since 2003 with a cure rate exceeding 85 percent, placing the Division among the best in the world. Together with Prof Dario Campana, NMRC STAR investigator and A/Prof Allen Yeoh from the Yong Loo Lin School of Medicine, the current Ma-Spore ALL 2010 is achieving better outcome with less chemotherapy for majority of patients. This is done by very sensitive and highly specific minimal residual disease (MRD) markers that can accurately risk stratify patients and tailor treatment to maximise cure and minimise side-effects.
In addition, the team has been conducting various cell-based immunotherapy in both leukaemias and solid tumours. Because of small families with few children, the lack of matched sibling donors have limited the number of haemopoietic stem cell transplants done in Singapore. Dr Tan Poh Lin, Head of Paediatric Blood and Bone Marrow Transplant has done > 50 haematopoietic stem cell transplants from parents (haploidentical HSCT). Dr Miriam Kimpo and Dr Chetan Dhamne are currently using anti-GD2 monoclonal therapy with natural killer cells against high risk neuroblastoma