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2024/01/25
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Dr Anand Jeyasekharan

Photo of Dr Anand Jeyasekharan

Designations:

  • Senior Consultant, Department of Haematology-Oncology, National University Cancer Institute, Singapore
  • Assistant Professor, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore

Qualifications:

MBBS (CMC Vellore, India), MRCP (UK), PhD (Cantab), FAMS (Medical Oncology)

Specialties/Sub-specialties:

Haematology, Medical Oncology

Special Interests:

Sarcomas, Lymphomas, Rare Cancers, and Targeting Genomic Instability in Cancer

Find Out More:

Biosketch

Dr Jeyasekharan obtained his undergraduate medical degree from Christian Medical College Vellore, India in 2003. He then received a Gates Cambridge Scholarship towards a PhD in Oncology (2008) at the University of Cambridge UK (Gonville and Caius College). Following a junior research fellowship in Cambridge (Wolfson), he joined the National University Hospital Singapore in 2010 to complete his training in Internal Medicine and Medical Oncology.

Dr Jeyasekharan has a special interest in the treatment of lymphomas/sarcomas, as well as personalized therapy for rare and advanced cancers. He holds a joint appointment at the Cancer Science Institute, where he runs a translational cancer research laboratory. His laboratory focuses on understanding how the tumour microenvironment impacts the efficacy of chemotherapy. Dr Jeyasekharan holds multiple internal and nationally funded grants to support his research, and is a platform lead for a national translational research program in cancer through the Singapore Translational Cancer Consortium (STCC).

Other Designations:

  • Principal Investigator, Cancer Science Institute of Singapore, NUS
  • Deputy Director, NUS Centre for Cancer Research (N2CR)
  • Research Director, Dept of Haematology-Oncology, NUH
  • Platform Lead, Translational Research Integration and Support Platform (Platform 3), Singapore Translational Cancer Consortium (STCC)

Awards

  • 2025: Senior Investigator, National Medical Research Council Clinician Scientist Awards
  • 2021: Clinician Scientist Award Investigator, National Medical Research Council Awards
  • 2017: Transition Award, National Medical Research Council Awards

Journals & Publications

  1. Lee RX, Mohd Abdul Rashid MB, Binte Meera Sahib NR, … , Lim ST, Chow EK, Jeyasekharan AD. Prospective Clinical Validation of a Combinatorial Functional Precision Medicine Platform in Relapsed/Refractory Non-Hodgkin's Lymphoma. JCO Precis Oncol. 2025 Jul;9:e2400780. doi: 10.1200/PO-24-00780.
  2. Cancila V, Bertolazzi G, Chan AS, … , Casola S*, Jeyasekharan AD*, Tripodo C*. Aggressive B-cell lymphomas retain ATR-dependent determinants of T-cell exclusion from the Germinal Center Dark Zone. J Clin Invest. 2025 Jul 17:e187371. doi: 10.1172/JCI187371.
  3. Sridhar S, Chan ASY, Jeyasekharan AD. Single-cell Resolved Oncogene Co-expression: From Principles to Clinical Impact. Blood Cancer Discov. 2025 Jul 1;6(4):288-292. doi: 10.1158/2643-3230.BCD-25-0064.
  4. Hoang PM, Torre D, Jaynes P, … , Kappei D, Guccione E, Jeyasekharan AD. A PRMT5-ZNF326 axis mediates innate immune activation upon replication stress. Sci Adv. 2024 Jun 7;10(23):eadm9589. doi: 10.1126/sciadv.adm9589.
  5. Liu M, Bertolazzi G, Sridhar S, …, Ng SB, Tripodo C, Jeyasekharan AD. Spatially-resolved transcriptomics reveal macrophage heterogeneity and prognostic significance in diffuse large B-cell lymphoma. Nat Commun. 2024 Mar 8;15(1):2113. doi: 10.1038/s41467-024-46220-z.
  6. Hoppe MM, Jaynes P, Shuangyi F, … , Ng SB, Tripodo C, Jeyasekharan AD. Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma. Cancer Discov. 2023 May 4;13(5):1144-1163. doi: 10.1158/2159-8290.CD-22-0998.
  7. Goh J, De Mel S, Hoppe MM, … , Lim ST, Chow EK, Jeyasekharan AD. An ex vivo platform to guide drug combination treatment in relapsed/refractory lymphoma. Sci Transl Med. 2022 Oct 19;14(667):eabn7824. doi: 10.1126/scitranslmed.abn7824.
  8. Srinivas US, Tay NSC, Jaynes P, … , Tam WL, Frezza C, Jeyasekharan AD. PLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production. Oncogene. 2022 Mar;41(13):1986-2002. doi: 10.1038/s41388-022-02219-8.
  9. Cross G, Ho JSY, Zacharias W, Jeyasekharan AD, Marazzi I. Emergency drug use in a pandemic: Harsh lessons from COVID-19. Cell. 2021 Oct 28;184(22):5497-5500. doi: 10.1016/j.cell.2021.09.025.
  10. Hoppe MM, Jaynes P, Wardyn JD, … , Pitt JJ, Tan DSP, Jeyasekharan AD. Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer. EMBO Mol Med. 2021 May 7;13(5):e13366. doi: 10.15252/emmm.202013366. 

Professional Memberships

  • Royal College of Physicians, London
  • Academy of Medicine, Singapore
  • Indian Medical Association - Member

2025/08/28
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