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2024/01/25
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Adj A/Prof Balamurugan A Vellayappan

Photo of Adj A/Prof Balamurugan A Vellayappan

Designations:

  • Senior Consultant, Department of Radiation Oncology, National University Cancer Institute, Singapore
  • Senior Consultant, Department of Oncology - Medical & Radiation, Ng Teng Fong General Hospital
  • Assistant Professor, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore

Qualifications:

MBBS (S'pore), GDFM(NUS), FRANZCR (Australia), Master of Clinical Investigation (NUS), Stereotactic fellowship (University of Ottawa)

Specialties/Sub-specialties:

Radiation Oncology

Special Interests:

Neuro-oncology (Malignant and benign conditions of brain and spine, including paediatric conditions), Haemato-oncology (Lymphoma, Myeloma, Leukemia), Gastrointestinal Cancer, Ablative radiation for metastatic disease (Radiosurgery / SBRT)

Biosketch

Dr Bala is a Senior Consultant in Radiation Oncology at the National University Cancer Institute, Singapore, and Chair of the Brain and Spine Cancer Programme. He treats patients with brain and spine tumours, blood cancers, and gastrointestinal cancers, with a particular focus on high-precision techniques such as stereotactic radiosurgery and SBRT.

He graduated from the National University of Singapore on the Dean’s List, and completed his specialist training with the Royal Australian and New Zealand College of Radiologists, where he received the CE Eddy medal as the top candidate across Australia, New Zealand and Singapore. He went on to further fellowship training in Sydney, and in stereotactic radiosurgery at the Ottawa Hospital Cyberknife Centre – one of the few Singaporean radiation oncologists with this training. He later completed proton therapy training at the Fred Hutchinson Cancer Centre in Seattle, and offers proton therapy for selected patients.

Research has always been part of how Dr Bala practises. As Research Director for the department, he leads research projects spanning RNA therapeutics for glioblastoma, radiation-friendly spine implants, and the diagnosis of radiation necrosis – work that has produced over 100 peer-reviewed publications. He remains involved in teaching, from undergraduate medical education at NUS to postgraduate examining for RANZCR, and has organised regional workshops to raise standards of care across the region.

At the heart of his practice is a simple belief – that patients and their families do best when they understand their options and are part of the decision. He aims to explain things clearly, and to walk alongside patients through the uncertainty that comes with a cancer diagnosis.

Away from the clinic, he can usually be found on his bicycle and takes part in the amateur racing scene.

Leadership Positions

  • 2025 – present : President-elect, Singapore Society for Neuro-oncology
  • 2023 – present : Chair, Brain and Spine Cancer Programme, NCIS
    2020 – present : Country Representative, Federation of Asian Organisations for Radiation Oncology
  • 2017 - present: Singapore Radiological Society EXCO and Subsection Chair
  • 2016 - present: Research Director

Awards

  • SHINE Award (NCIS) 2018, 2026
  • NUH Incredible Care Service Champion (Bronze) 2024
  • Fung Fellowship (Fung Foundation) 2018
  • NUH Long service award (10 years) 2016
  • Stereotactic Fellowship (University of Ottawa) 2015
  • CE Eddy Prize (FRANZCR) 2010
  • GDFM Book Prize (GDFM) 2009
  • Wong Poi Kwong Gold Medal in Medicine (MBBS) 2005
  • Dean's List (MBBS) 2005

Journals & Publications

Over 100 peer-reviewed publications. Citations: 5,284 | h-index: 29 | i10-index: 61 (Google Scholar)

Selected Publications

  1. Srinivas US, Tan BWQ, Vellayappan BA, Jeyasekharan AD. ROS and the DNA damage response in cancer. Redox Biol. 2019 Jul;25:101084. doi: 10.1016/j.redox.2018.101084. (Cited by 2,426)Vellayappan B, Tan CL, Yong C, Khor LK, Koh
  2. WY, Yeo TT, Detsky J, Lo S, Sahgal A. Diagnosis and Management of Radiation Necrosis in Patients With Brain Metastases. Front Oncol. 2018 Sep 28;8:395. doi: 10.3389/fonc.2018.00395. (Cited by 272)
  3. Kazmi F, Soon YY, Leong YH, Koh WY, Vellayappan B. Re-irradiation for recurrent glioblastoma (GBM): a systematic review and meta-analysis. J Neurooncol. 2019 Mar;142(1):79-90. doi: 10.1007/s11060-018-03064-0. (Cited by 203)
  4. Vellayappan BA, Soon YY, Ku GY, Leong CN, Lu JJ, Tey JC. Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer. Cochrane Database Syst Rev. 2017 Aug 22;8(8):CD010511. doi: 10.1002/14651858.CD010511.pub2. (Cited by 149)
  5. Tay SH, Toh MMX, Thian YL, Vellayappan BA, Fairhurst AM, Chan YH, et al. Cytokine release syndrome in cancer patients receiving immune checkpoint inhibitors: a case series of 25 patients and review of the literature. Front Immunol. 2022;13:807050. (Cited by 131)
  6. Vellayappan B, Lim-Fat MJ, Kotecha R, De Salles A, Fariselli L, Levivier M, et al. A systematic review informing the management of symptomatic brain radiation necrosis after stereotactic radiosurgery and international stereotactic radiosurgery society practice recommendations. Int J Radiat Oncol Biol Phys. 2024;118(1):14-28. (Cited by 111)
  7. Tey J, Soon YY, Koh WY, Leong CN, Choo BA, Ho F, Vellayappan B, et al. Palliative radiotherapy for gastric cancer: a systematic review and meta-analysis. Oncotarget. 2017;8(15):25797. (Cited by 111)
  8. Kumar N, Tan WLB, Wei W, Vellayappan BA. An overview of the tumors affecting the spine—inside to out. Neurooncol Pract. 2020;7(Suppl_1):i10-i17. (Cited by 99)
  9. Kumar N, Malhotra R, Zaw AS, Maharajan K, Naresh N, Kumar A, et al. Evolution in treatment strategy for metastatic spine disease: presently evolving modalities. Eur J Surg Oncol. 2017;43(9):1784-1801. (Cited by 72)
  10. Ngoi N, Lim J, Ow S, Jen WY, Lee M, Teo J, Ho J, Sundar R, Tung ML, et al. A segregated-team model to maintain cancer care during the COVID-19 outbreak at an academic center in Singapore. Ann Oncol. 2020;31(7):840-843. (Cited by 59)

2026/09/10
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